{
  "abstract": "Tuberculous pleuritis (TBP) remains one of the most diagnostically challenging manifestations of tuberculosis.1 2 Despite its global prevalence, particularly in high-burden settings, confirmation of TBP is frequently elusive. Conventional microbiological techniques perform poorly in pleural fluid,3 4 where mycobacterial burden is low and organisms are often non-viable. Diagnostic confidence is therefore commonly inferred from surrogate markers such as adenosine deaminase (ADA), immunological assays5 6 or clinical response to therapy. The result is a persistent trade-off between diagnostic delay, empirical treatment and invasive pleural biopsy.",
  "authors": [
    {
      "affiliations": [
        "Oxford Respiratory Trials Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK",
        "Oxford Pleural Unit, Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"
      ],
      "name": "Eihab O Bedawi"
    },
    {
      "affiliations": [
        "Oxford Respiratory Trials Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK",
        "Oxford Pleural Unit, Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK",
        "Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK"
      ],
      "name": "Najib M Rahman"
    }
  ],
  "title": "Rethinking pleural tuberculosis through the lens of cell-free DNA",
  "uid": "cc03e3c9-96a9-5570-98d5-c9a3cfcf377d"
}