{
  "abstract": "Dietary nitrate (NO₃−) supplementation has been shown to improve vascular function and exercise capacity in chronic obstructive pulmonary disease and in pulmonary hypertension. In a double-blind, placebo-controlled crossover study in 20 patients with idiopathic pulmonary fibrosis who desaturated on exercise, endurance shuttle walk test improved by a median (IQR) difference of 31 s (–9.5 to 100.0; (p=0.043)), following a single dose of 140 mL NO₃− rich beetroot juice, as did brachial artery flow mediated dilatation; +4.25% (95% CI –0.71% to 8.45%; p=0.036), compared with following placebo NO₃− depleted placebo juice. Longer-term studies are needed to see if these acute effects translate into sustained benefit.ISRCTN14888729. Registration date 14 July 2015, https://doi.org/10.1186/ISRCTN14888729",
  "authors": [
    {
      "affiliations": [
        "Imperial College London NHLI, London, UK",
        "Royal Brompton and Harefield Hospitals, London, UK",
        "King Abdulaziz University, Jeddah, Makkah Province, Saudi Arabia"
      ],
      "name": "Mansour S Majrshi"
    },
    {
      "affiliations": [
        "Respiratory Medicine, Royal Brompton and Harefield Hospitals, London, UK",
        "Respiratory Therapy Department, Taibah University, Medina, Saudi Arabia"
      ],
      "name": "Ahmed A Alzahrani"
    },
    {
      "affiliations": [
        "Interstitial Lung Disease Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK"
      ],
      "name": "Peter M George"
    },
    {
      "affiliations": [
        "Imperial College London NHLI, London, UK"
      ],
      "name": "Alexis Perkins"
    },
    {
      "affiliations": [
        "Imperial College London NHLI, London, UK"
      ],
      "name": "Keir E J Philip"
    },
    {
      "affiliations": [
        "King Abdulaziz University, Jeddah, Makkah Province, Saudi Arabia"
      ],
      "name": "Mona S Alshehri"
    },
    {
      "affiliations": [
        "Imperial College London NHLI, London, UK"
      ],
      "name": "Peter S Fenwick"
    },
    {
      "affiliations": [
        "Respiratory Therapy Program, Department of Nursing, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia"
      ],
      "name": "Abdullah S Alsulayyim"
    },
    {
      "affiliations": [
        "National Pulmonary Hypertension Service, Royal Brompton and Harefield NHS Foundation Trust, London, UK",
        "NHLI, Imperial College London Faculty of Medicine, London, UK"
      ],
      "name": "Laura C Price"
    },
    {
      "affiliations": [
        "Royal Brompton and Harefield Hospitals, London, UK",
        "Guy’s and St Thomas’ NHS Foundation Trust, London, UK"
      ],
      "name": "Michael I Polkey"
    },
    {
      "affiliations": [
        "Imperial College London NHLI, London, UK",
        "Royal Brompton and Harefield NHS Trust, London, UK"
      ],
      "name": "Nicholas S Hopkinson"
    }
  ],
  "title": "Effect of Dietary Nitrate Supplementation on Exercise Performance in Hypoxic IPF (EDEN-OX3): a double-blind, placebo-controlled, randomised crossover study",
  "uid": "fb671a89-6a41-5a75-8988-25a18925072c"
}