{
  "abstract": "Plasma circulating tumour DNA (ctDNA) has a low detection rate for isolated malignant pleural effusion (MPE) in non-small cell lung cancer (NSCLC). Pleural fluid cell free DNA (cfDNA) detects all extracellular DNA fragments, not limited to DNA from tumour cells, and may improve detection rates. Wang et al (European Journal of Cancer, 2025; 217; https://doi.org/10.1016/j.ejca.2025.115224) conducted a prospective study of 50 patients with cytology positive newly diagnosed NSCLC with MPE, comparing pleural cfDNA next generation sequencing (NGS) with pleural cell pellet Sanger sequencing and routine tissue testing.",
  "authors": [
    {
      "affiliations": [
        "Oxford Pleural Unit, Oxford University Hospitals, Oxford, UK"
      ],
      "name": "Dahlia Abdul-Rahman"
    }
  ],
  "title": "Journal club",
  "uid": "e3900a23-6997-5a99-aa39-7b1b5e224c56"
}