{
  "abstract": "Background Asbestos, mineral wool (MW), refractory ceramic fibres (RCF) and silica are among the most common exposures to mineral particles in the workplace.Objective To study the effect of coexposure to asbestos and MW, crystalline silica or RCFs and the risk of lung cancer and mesothelioma.Methods The Asbestos-Related Diseases Cohort is a surveillance programme in retired workers exposed to asbestos during their working life. Complete job histories were collected and occupational exposure to asbestos was assessed by an expert, while occupational exposure to MW, RCFs and silica was assessed using French job-exposure matrices. Cox proportional hazards models were used to estimate HR and 95% CI for lung cancer mortality and lung cancer incidence and for mesothelioma mortality or mesothelioma incidence.Results In this population of workers exposed to asbestos, in the mortality study, exposures to MW, crystalline silica and RCFs were not found to be associated with lung cancer after adjustment for smoking and asbestos, nor with mesothelioma after adjustment for asbestos. In the incidence study, there was an association between exposure to crystalline silica (ever exposed) and mesothelioma (HR a=1.75, 95% CI 1.17 to 2.62).Conclusion Crystalline silica is not known to induce mesothelioma but coexposure to asbestos could increase the effect of asbestos on the mesothelial cells.",
  "authors": [
    {
      "affiliations": [
        "CHU de Bordeaux, Bordeaux, France",
        "Bordeaux Population Health Research Center, Equipe EPICENE, INSERM U1219, Bordeaux, France"
      ],
      "name": "Fleur Delva"
    },
    {
      "affiliations": [
        "Bordeaux Population Health Research Center, Equipe EPICENE, INSERM U1219, Bordeaux, France"
      ],
      "name": "Céline Gramond"
    },
    {
      "affiliations": [
        "Université de Lorraine, Inserm, INSPIIRE, Nancy, France"
      ],
      "name": "Isabelle Thaon"
    },
    {
      "affiliations": [
        "Bordeaux Population Health Research Center, Equipe EPICENE, INSERM U1219, Bordeaux, France"
      ],
      "name": "Aude Lacourt"
    },
    {
      "affiliations": [
        "Bordeaux Population Health Research Center, Equipe EPICENE, INSERM U1219, Bordeaux, France"
      ],
      "name": "Patrick Brochard"
    },
    {
      "affiliations": [
        "Institut Interuniversitaire de Médecine du Travail de Paris-Ile de France, Créteil, France"
      ],
      "name": "Julia Benoist"
    },
    {
      "affiliations": [
        "Occupational Diseases Department, Rouen University Hospital, Rouen, France"
      ],
      "name": "Antoine Gislard"
    },
    {
      "affiliations": [
        "University of Bordeaux, Bordeaux, France"
      ],
      "name": "Francois Laurent"
    },
    {
      "affiliations": [
        "Occupational Diseases, University Hospital Centre Rennes, Rennes, France"
      ],
      "name": "Christophe Paris"
    },
    {
      "affiliations": [
        "Institut Interuniversitaire de Médecine du Travail de Paris-Ile de France, Créteil, France",
        "Service de Pneumologie et Pathologie Professionnelle, Centre Hospitalier Intercommunal de Créteil, Créteil, France",
        "INSERM U955, Créteil, France"
      ],
      "name": "Pascal Andujar"
    },
    {
      "affiliations": [
        "Service de Santé au Travail et Pathologie Professionnelle, CHU Caen, Caen, France",
        "Faculté de Médecine, Université de Caen Normandie, Caen, France",
        "ANTICIPE, INSERM U1086, Caen, France"
      ],
      "name": "Bénédicte Clin"
    },
    {
      "affiliations": [
        "Institut Interuniversitaire de Médecine du Travail de Paris-Ile de France, Créteil, France",
        "Service de Pneumologie et Pathologie Professionnelle, Centre Hospitalier Intercommunal de Créteil, Créteil, France",
        "INSERM U955, Créteil, France"
      ],
      "name": "Jean-Claude Pairon"
    }
  ],
  "title": "Coexposure to asbestos, mineral wool, crystalline silica and refractory ceramic fibres and risk of lung cancer and mesothelioma",
  "uid": "159beb05-2739-5bd7-96b7-1dcb3f762aca"
}