{
  "abstract": "Elevated troponin I (TnI) has been reported in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease (CVD), suggesting non-ischaemic mechanisms. We assessed this association in a population-based cohort of 22 526 individuals without known CVD or significant coronary artery calcification. TnI showed no association with COPD (adjusted OR 0.87, 95% CI 0.60 to 1.26; highest category vs below limit of detection) or with forced expiratory volume in 1 s/forced vital capacity (adjusted difference 0.002, 95% CI −0.001 to 0.004). Median TnI was 2.2 ng/L in both obstructive and non-obstructive groups. These findings do not support a pulmonary source of TnI elevation in mild to moderate, stable COPD and suggest that TnI elevations should prompt cardiovascular evaluation rather than being attributed to pulmonary disease alone.",
  "authors": [
    {
      "affiliations": [
        "Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden"
      ],
      "name": "Jonas Eriksson Ström"
    },
    {
      "affiliations": [
        "Division for Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden",
        "Department of Respiratory Medicine and Allergy, Karolinska Severe COPD Center, Karolinska University Hospital, Stockholm, Sweden"
      ],
      "name": "Ida Pesonen"
    },
    {
      "affiliations": [
        "Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden"
      ],
      "name": "Per Liv"
    },
    {
      "affiliations": [
        "COPD Center, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden",
        "COPD Center, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"
      ],
      "name": "Anders Andersson"
    },
    {
      "affiliations": [
        "Department of Respiratory Medicine and Allergy, Karolinska Severe COPD Center, Karolinska University Hospital, Stockholm, Sweden",
        "Division for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden",
        "Lung Laboratory, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden"
      ],
      "name": "Apostolos Bossios"
    },
    {
      "affiliations": [
        "Respiratory Medicine, Allergology and Palliative Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden",
        "Skåne University Hospital, Lund, Sweden"
      ],
      "name": "Arne Egesten"
    },
    {
      "affiliations": [
        "Respiratory Medicine, Allergology and Palliative Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden"
      ],
      "name": "Magnus Ekström"
    },
    {
      "affiliations": [
        "Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden",
        "Departments of Clinical Physiology and Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden"
      ],
      "name": "Jan Engvall"
    },
    {
      "affiliations": [
        "Departments of Cardiology and Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden"
      ],
      "name": "Elin Good"
    },
    {
      "affiliations": [
        "Department of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden"
      ],
      "name": "Ola Hammarsten"
    },
    {
      "affiliations": [
        "Department of Cardiothoracic and Vascular Surgery, Linköping University Hospital, Linköping, Sweden",
        "Department of Health, Medicine and Caring Sciences, Unit of Cardiovascular Medicine, Linköping University, Linköping, Sweden"
      ],
      "name": "Jonas Holm"
    },
    {
      "affiliations": [
        "Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden"
      ],
      "name": "Christer Janson"
    },
    {
      "affiliations": [
        "Region Västra Götaland, Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden",
        "Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"
      ],
      "name": "Åse Johnsson"
    },
    {
      "affiliations": [
        "Department of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden"
      ],
      "name": "Lars Lind"
    },
    {
      "affiliations": [
        "Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden"
      ],
      "name": "Eva Lindberg"
    },
    {
      "affiliations": [
        "Department of Respiratory Medicine and Allergy, Karolinska Severe COPD Center, Karolinska University Hospital, Stockholm, Sweden",
        "Division for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden"
      ],
      "name": "Anders Lindén"
    },
    {
      "affiliations": [
        "Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden"
      ],
      "name": "Andrei Malinovschi"
    },
    {
      "affiliations": [
        "Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden"
      ],
      "name": "Anna Moberg"
    },
    {
      "affiliations": [
        "Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden"
      ],
      "name": "Ulf Nilsson"
    },
    {
      "affiliations": [
        "Region Västra Götaland, Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden",
        "Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"
      ],
      "name": "Emma Palmqvist"
    },
    {
      "affiliations": [
        "Division for Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden",
        "Department of Respiratory Medicine and Allergy, Karolinska Severe COPD Center, Karolinska University Hospital, Stockholm, Sweden"
      ],
      "name": "Magnus Skold"
    },
    {
      "affiliations": [
        "Department of Respiratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden"
      ],
      "name": "Josefin Sundh"
    },
    {
      "affiliations": [
        "Department of Respiratory Medicine, Skåne University Hospital, Lund University, Malmö, Sweden"
      ],
      "name": "Hanan A Tanash"
    },
    {
      "affiliations": [
        "Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden",
        "Department of Respiratory Medicine, Skåne University Hospital, Lund University, Malmö, Sweden",
        "Department of Clinical Sciences, Lund University, Lund, Sweden"
      ],
      "name": "Suneela Zaigham"
    },
    {
      "affiliations": [
        "Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden"
      ],
      "name": "Anders Blomberg"
    }
  ],
  "title": "No association between troponin and COPD without cardiovascular influence: findings from a population-based cohort (SCAPIS)",
  "uid": "5abfcaa5-c84b-5b24-9623-b20e7f62d376"
}