{
  "abstract": "Exercise-induced desaturation is poorly recognised in lymphangioleiomyomatosis (LAM) and its relationship to outcome is unknown. In a UK cohort study, 37% of 131 women with LAM experienced exercise-induced desaturation to <88% during a 6 min walk test. Forced expiratory volume in 1 s (FEV1) and DLCO were associated with walk parameters but had poor predictive accuracy for exercise-induced desaturation. A 5-year follow-up showed exercise-induced desaturation at baseline was associated with rapid FEV1 decline (p=0.008) and need for rapamycin treatment (p=0.00001). Women with LAM should be evaluated for exercise-induced desaturation to target ambulatory oxygen and improve identification of those at risk of poor outcomes.",
  "authors": [
    {
      "affiliations": [
        "Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham Faculty of Medicine and Health Sciences, Nottingham, UK"
      ],
      "name": "Jan Johnson"
    },
    {
      "affiliations": [
        "Centre for Respiratory Research, NIHR Biomedical Research Centre and Biodiscovery Institute, Translational Medical Sciences, School of Medicine and National Centre for LAM, University of Nottingham, Nottingham, UK"
      ],
      "name": "Simon R Johnson"
    }
  ],
  "title": "Prevalence and assessment of exercise-induced desaturation in lymphangioleiomyomatosis",
  "uid": "bc3af0db-4942-5a44-889b-74eb92e89fd0"
}