{
  "abstract": "Objectives To test the feasibility and safety of exercise as an airway clearance technique (ExACT) for people with cystic fibrosis (pwCF) versus usual care (UC).Methods Dual-site, two-arm randomised pilot trial. Fifty pwCF (≥10 years, forced expiratory volume in 1 s (FEV 1) ≥40% predicted), stable on Elexacaftor/Tezacaftor/Ivacaftor, were recruited, of whom 48 were randomly assigned (1:1 with minimisation) to daily ExACT (stopping all other airway clearance techniques) or UC. Feasibility was measured by recruitment, retention and adherence against preset progression criteria. Key measures of safety and signals of efficacy included spirometry (FEV1), lung clearance index (LCI2.5), pulmonary exacerbations, physical activity, treatment burden and quality of life across 28 days. Qualitative interview data and preliminary health economic data were also collected.Findings ExACT was safe over 28 days, measured by change in LCI 2.5 (ExACT −0.1 (0.6) vs UC 0.2 (0.8), mean (SD)) and FEV1 (ExACT +2.1 (6.6) vs UC −0.8 (5.5), % predicted mean (SD)). Relative (ExACT/UC) differences of 0.97 (0.92, 1.02) for LCI2.5 and absolute differences (ExACT-UC) of 3.2 (−0.6, 6.9) % predicted for FEV1 suggest potential intervention efficacy. Few adverse events were reported; none serious. Recruitment and retention data suggest progression to a definitive trial, with 48/117 (41% of approached) randomised, 45/48 (92%) completing the study and a 60% overall adherence rate.Discussion Testing of our primary hypothesis within a feasibility trial showed ExACT to be a safe, acceptable and feasible intervention for pwCF. These data support advancement to a definitive, longer-term, multisite trial evaluating the safety, efficacy and cost-effectiveness of ExACT, following minor refinement.Trial registration number NCT05482048.",
  "authors": [
    {
      "affiliations": [
        "Department of Child Life and Health, University of Edinburgh, Edinburgh, UK",
        "Department of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children and Young People, Edinburgh, UK"
      ],
      "name": "Don S Urquhart"
    },
    {
      "affiliations": [
        "Department of Child Life and Health, University of Edinburgh, Edinburgh, UK",
        "Department of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children and Young People, Edinburgh, UK"
      ],
      "name": "Emily Taylor"
    },
    {
      "affiliations": [
        "Department of Child Life and Health, University of Edinburgh, Edinburgh, UK",
        "Department of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children and Young People, Edinburgh, UK",
        "Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK"
      ],
      "name": "Steve Cunningham"
    },
    {
      "affiliations": [
        "Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK"
      ],
      "name": "Steff Lewis"
    },
    {
      "affiliations": [
        "Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK"
      ],
      "name": "Aileen Rae Neilson"
    },
    {
      "affiliations": [
        "Department of Psychology, Sport and Exercise Sciences, University of Portsmouth, Portsmouth, UK"
      ],
      "name": "Dia Soilemezi"
    },
    {
      "affiliations": [
        "Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK"
      ],
      "name": "Hannah Ensor"
    },
    {
      "affiliations": [
        "Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, UK"
      ],
      "name": "Ioannis Vogiatzis"
    },
    {
      "affiliations": [
        "Cystic Fibrosis Trust, London, UK"
      ],
      "name": "Lorna J Allen"
    },
    {
      "affiliations": [
        "School of Health Sciences, University of Southampton, Southampton, UK",
        "Wessex Cystic Fibrosis Unit, University Hospitals Southampton NHS Foundation Trust, Southampton, UK",
        "NIHR Southampton Biomedical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK"
      ],
      "name": "Zoe Louise Saynor"
    },
    {
      "affiliations": [],
      "name": "ExACT-CF Study Group"
    }
  ],
  "title": "Safety, feasibility and efficacy of exercise as an airway clearance technique in cystic fibrosis: a randomised pilot feasibility trial",
  "uid": "5ceeebe0-fcf0-593d-863c-51bd07a2a2c2"
}