{
  "abstract": "Reduced diffusing capacity of the lungs for carbon monoxide (DLco) reflects microvasculopathy in chronic thromboembolic pulmonary hypertension, yet its clinical value is uncertain. In a Japanese nationwide registry (2018–2023) we studied 1270 patients: 486 formed an event cohort and 299 a treatment cohort who underwent pulmonary endarterectomy or balloon pulmonary angioplasty. Lower baseline DLco was indicative of smaller postprocedural improvements in mean pulmonary artery pressure, pulmonary vascular resistance and cardiac index (all p≤0.023) and a higher risk of clinical events (HR 0.971, p=0.005). Outcomes deteriorated below 59.6%, indicating DLco may help stratify prognosis and treatment benefit.",
  "authors": [
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan"
      ],
      "name": "Shun Minatsuki"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan"
      ],
      "name": "Masaru Hatano"
    },
    {
      "affiliations": [
        "Center for Clinical and Translational Research, Kyushu University Hospital, Fukuoka, Japan"
      ],
      "name": "Kouta Funakoshi"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan"
      ],
      "name": "Yu Taniguchi"
    },
    {
      "affiliations": [
        "Department of Cardiology, Nagoya University, Nagoya, Japan"
      ],
      "name": "Shiro Adachi"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Kyorin University School of Medicine, Tokyo, Japan"
      ],
      "name": "Takumi Inami"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Kyushu University, Fukuoka, Japan"
      ],
      "name": "Kazuya Hosokawa"
    },
    {
      "affiliations": [
        "Department of Cardiology, Tokyo Medical University, Tokyo, Japan"
      ],
      "name": "Jun Yamashita"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Surgery, Tokyo Medical University, Tokyo, Japan"
      ],
      "name": "Hitoshi Ogino"
    },
    {
      "affiliations": [
        "Division of Respiratory and Cardiovascular Innovative Research, Hokkaido University, Sapporo, Japan"
      ],
      "name": "Ichizo Tsujino"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Tohoku University Hospital, Sendai, Japan"
      ],
      "name": "Nobuhiro Yaoita"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Toho University Medical Center Ohashi Hospital, Tokyo, Japan"
      ],
      "name": "Nobutaka Ikeda"
    },
    {
      "affiliations": [
        "Department of Pulmonary Hypertension Center, Chibaken Saiseikai Narashino Hospital, Narashino, Japan"
      ],
      "name": "Nobuhiro Tanabe"
    },
    {
      "affiliations": [
        "Department of Cardiology, National Hospital Organization Okayama Medical Center, Okayama, Japan"
      ],
      "name": "Hiroto Shimokawahara"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine and Hypertension, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan"
      ],
      "name": "Kayoko Kubota"
    },
    {
      "affiliations": [
        "Department of Respirology, Chiba University Graduate School of Medicine, Chiba, Japan"
      ],
      "name": "Ayako Shigeta"
    },
    {
      "affiliations": [
        "Department of Respirology, Chiba University Graduate School of Medicine, Chiba, Japan"
      ],
      "name": "Koichiro Tatsumi"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Matsuyama Red Cross Hospital, Matsuyama, Japan"
      ],
      "name": "Koshin Horimoto"
    },
    {
      "affiliations": [
        "Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan"
      ],
      "name": "Yoshito Ogihara"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Kure Kyosai Hospital, Kure, Japan"
      ],
      "name": "Yoshihiro Dohi"
    },
    {
      "affiliations": [
        "Department of Cardiology, Keio University School of Medicine, Tokyo, Japan"
      ],
      "name": "Takahiro Hiraide"
    },
    {
      "affiliations": [
        "Division of Cardiology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan"
      ],
      "name": "Takashi Kawakami"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Nephrology, and Neurology, University of the Ryukyus, Okinawa, Japan"
      ],
      "name": "Hidekazu Ikemiyagi"
    },
    {
      "affiliations": [
        "Pulmonary Hypertension Center, International University of Health and Welfare Mita Hospital, Tokyo, Japan"
      ],
      "name": "Yuichi Tamura"
    },
    {
      "affiliations": [
        "Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan"
      ],
      "name": "Yoshihiro Fukumoto"
    },
    {
      "affiliations": [
        "Department of Cardiovascular Medicine, Kyushu University, Fukuoka, Japan"
      ],
      "name": "Kohtaro Abe"
    },
    {
      "affiliations": [],
      "name": "on behalf of CTEPH AC Registry Study Group"
    }
  ],
  "title": "Significance of diffusing capacity of the lungs for carbon monoxide on chronic thromboembolic pulmonary hypertension",
  "uid": "930535e7-b615-5e47-9f5e-47b719658286"
}