{
  "abstract": "For decades, most critical care patients have survived hospitalisation, supporting increased attention on the long-term critical illness recovery. The term ‘Post-Intensive Care Syndrome’ was coined in 2012 to raise awareness of long-term impairment in physical, cognitive and/or mental health after critical illness. However, the incidence of these impairments has persisted over the past decade, reaching as high as 60% and remains a major public health problem.Aiming to set a research agenda to address evidence gaps in critical illness recovery over the next 10 years, we invited key international opinion leaders from diverse clinical and methodological backgrounds to a roundtable meeting in June 2024 to assess the progress of post-critical illness recovery research and outline a future research agenda to address the unmet needs of critical illness survivors over the next decade.An early outcome from the meeting was to conduct a thematic analysis of critical care recovery literature, which highlighted the need for effective expectation management, ongoing patient support and education throughout recovery, integration between inpatient and community care, caregiver support and opportunities to reconnect with the intensive care unit.Participants identified conceptual challenges concerning current terminology and scope, population heterogeneity and phenotyping, and outcome definitions. Methodological challenges were identified around study design, with a call to shift to contemporary trial designs, incorporating qualitative methods. Translation into clinical practice will require interdisciplinary engagement.The roundtable concluded that a roadmap should be developed to guide clinical and research efforts over the coming decade, with the aim of developing a precision recovery approach.",
  "authors": [
    {
      "affiliations": [
        "Department of Mental Health, Caboolture Hospital, Caboolture, Queensland, Australia",
        "The Prince Charles Hospital, Chermside, Queensland, Australia",
        "Queensland University of Technology, Brisbane, Queensland, Australia",
        "The University of Queensland, Brisbane, Queensland, Australia"
      ],
      "name": "Dylan Flaws"
    },
    {
      "affiliations": [
        "Queen’s University Belfast, Belfast, UK"
      ],
      "name": "Jonathan D Stewart"
    },
    {
      "affiliations": [
        "Physiotherapy, Western Health, Footscray, Victoria, Australia",
        "Faculty of Medicine Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Kimberley Joy Haines"
    },
    {
      "affiliations": [
        "School of Medicine, University of Queensland, Herston, Queensland, Australia",
        "Critical Care Research Group, Chermside, Queensland, Australia",
        "Intensive Care, St Andrew’s War Memorial Hospital, Brisbane, Queensland, Australia"
      ],
      "name": "John F Fraser"
    },
    {
      "affiliations": [
        "ICU, QUB, Belfast, UK",
        "Centre for Experimental Medicine, Queen’s University Belfast, Belfast, UK"
      ],
      "name": "Daniel Francis McAuley"
    },
    {
      "affiliations": [
        "The Prince Charles Hospital, Chermside, Queensland, Australia",
        "The University of Queensland, Brisbane, Queensland, Australia"
      ],
      "name": "Sue E Patterson"
    },
    {
      "affiliations": [
        "Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia",
        "School of Public Health and Preventive Medicine, Department of Epidemiology and Preventative Medicine, Monash University, Melbourne, Victoria, Australia",
        "Intensive Care Unit, Alfred Hospital, Melbourne, Victoria, Australia",
        "Department of Critical Care, The George Institute for Global Health, Sydney, New South Wales, Australia"
      ],
      "name": "Carol L Hodgson"
    },
    {
      "affiliations": [
        "Department of Critical Care Medicine, Alberta Health Services, Edmonton, Alberta, Canada"
      ],
      "name": "Sarah K Andersen"
    },
    {
      "affiliations": [
        "Critical Care, University of Alberta, Edmonton, Alberta, Canada"
      ],
      "name": "Sean M Bagshaw"
    },
    {
      "affiliations": [
        "Departments of Pharmacy and Critical Care, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK",
        "Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK",
        "University of Manchester, North Manchester, National Institute for Health and Care Research (NIHR) Greater Manchester Patient Safety Research Collaboration (PSRC), Scho, UK"
      ],
      "name": "Richard S Bourne"
    },
    {
      "affiliations": [
        "Queen’s University Belfast Wellcome-Wolfson Institute for Experimental Medicine, Belfast, UK",
        "Department of Critical Care, School of Medicine, The University of Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Bronwen Connolly"
    },
    {
      "affiliations": [
        "Department of Medicine, Division of Respiratory and Critical Care, National University of Singapore, Singapore"
      ],
      "name": "Matthew Cove"
    },
    {
      "affiliations": [
        "King’s College London, London, UK",
        "Ageing and Health, Guy and St Thomas’ NHS Foundation Trust, London, UK"
      ],
      "name": "Jugdeep Dhesi"
    },
    {
      "affiliations": [
        "School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast Wellcome-Wolfson Institute for Experimental Medicine, Belfast, UK"
      ],
      "name": "Sallyanne Duncan"
    },
    {
      "affiliations": [
        "ICNARC, London, UK"
      ],
      "name": "Doug Gould"
    },
    {
      "affiliations": [
        "The Healthcare Improvement Studies Institute, University of Cambridge Clinical School, Cambridge, UK",
        "Department of Physiotherapy, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"
      ],
      "name": "Peter Hartley"
    },
    {
      "affiliations": [
        "Department of Critical Care, The George Institute for Global Health, Sydney, New South Wales, Australia",
        "ANZIC-RC, SPHPM, Monash University Faculty of Medicine Nursing and Health Sciences, Melbourne, Victoria, Australia"
      ],
      "name": "Lisa Higgins"
    },
    {
      "affiliations": [
        "Oregon Health & Science University, Portland, Oregon, USA"
      ],
      "name": "Catherine L Hough"
    },
    {
      "affiliations": [
        "Anaesthesia and Critical Care, Makerere University CHS, Kampala, Uganda",
        "Department of Anaesthesiology and Critical Care, Makerere University, Kampala, Uganda"
      ],
      "name": "Arthur Kwizera"
    },
    {
      "affiliations": [
        "Department of Critical Care, The University of Melbourne, Melbourne, Victoria, Australia",
        "Department of Physiotherapy, Western Health, Footscray, Victoria, Australia"
      ],
      "name": "Nina Leggett"
    },
    {
      "affiliations": [
        "Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK"
      ],
      "name": "Mary Ni Lochlainn"
    },
    {
      "affiliations": [
        "Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK",
        "Department of Critical Care, Royal Infirmary of Edinburgh, Edinburgh, UK"
      ],
      "name": "Nazir I Lone"
    },
    {
      "affiliations": [
        "Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde, Glasgow, UK"
      ],
      "name": "Pamela MacTavish"
    },
    {
      "affiliations": [
        "NIHR Policy Research Unit in Health & Social Care Workforce, King’s College London, London, UK"
      ],
      "name": "Jill Manthorpe"
    },
    {
      "affiliations": [
        "Associação Hospital Moinhos de Vento, Porto Alegre, Brazil"
      ],
      "name": "Duane Mocellin"
    },
    {
      "affiliations": [
        "Department of Medicine, University of Colorado, Aurora, Colorado, USA"
      ],
      "name": "Mark E Mikkelsen"
    },
    {
      "affiliations": [
        "School of Clinical and Experimental Medicine, Centre for Translational Inflammation and Fibrosis Research, University of Birmingham, Birmingham, UK",
        "Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"
      ],
      "name": "Dhruv Parekh"
    },
    {
      "affiliations": [
        "Escritório de Projetos - PROADI/SUS, Hospital Moinhos de Vento, Porto Alegre, Brazil",
        "Brazilian Research in Intensive Care Network, São Paulo, Brazil",
        "Faculty of Medicine, Universidade Federal do Rio de Janeiro, Porto Alegre, Brazil"
      ],
      "name": "Regis Goulart Rosa"
    },
    {
      "affiliations": [
        "ICNARC, London, UK"
      ],
      "name": "Kathryn Rowan"
    },
    {
      "affiliations": [
        "Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK"
      ],
      "name": "Charlotte Summers"
    },
    {
      "affiliations": [
        "Critical Care Research Group, Chermside, Queensland, Australia",
        "Institute of Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia",
        "Speech and Language Therapy, Barts Health NHS Trust, London, UK"
      ],
      "name": "Anna-Liisa Sutt"
    },
    {
      "affiliations": [
        "Division of Hospital Medicine, University of Michigan, Ann Arbor, Michigan, USA"
      ],
      "name": "Stephanie Parks Taylor"
    },
    {
      "affiliations": [
        "Brazilian Research in Intensive Care Network, São Paulo, Brazil",
        "Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil"
      ],
      "name": "Cassiano Teixeira"
    },
    {
      "affiliations": [
        "Critical Care Research Group, Chermside, Queensland, Australia",
        "Physiotherapy Department, The Prince Charles Hospital, Chermside, Queensland, Australia"
      ],
      "name": "Oystein Tronstad"
    },
    {
      "affiliations": [
        "Department of Critical Care Medicine, Alberta Health Services, Edmonton, Alberta, Canada",
        "Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada"
      ],
      "name": "M Elizabeth Wilcox"
    },
    {
      "affiliations": [
        "Department of Critical Care, NHS Lothian, Edinburgh, UK",
        "Department of Anesthesiology, Emory University Hospital, Atlanta, Georgia, USA"
      ],
      "name": "Elizabeth Wilson"
    },
    {
      "affiliations": [
        "Intensive Care Unit, Gold Coast University Hospital, Southport, Queensland, Australia",
        "Critical Care Research Group, Gold Coast University Hospital, Southport, Queensland, Australia"
      ],
      "name": "James Winearls"
    },
    {
      "affiliations": [
        "The Healthcare Improvement Studies Institute, University of Cambridge, Cambridge, UK"
      ],
      "name": "Joanne McPeake"
    }
  ],
  "title": "Greater recovery after critical illness (GRACE): a call to action to create a new roadmap for critical illness research",
  "uid": "c7b86235-5f85-5887-af0e-044775583c0b"
}