{
  "abstract": "Critical illness poses a significant global health challenge, disproportionately affecting low- and middle-income countries (LMICs) and other low-resource settings, where healthcare resources and infrastructure are often limited. This narrative review explores the multifaceted dynamics of critical care research in low-resource settings, focusing on socioeconomic, demographic and structural barriers that impact the delivery of intensive care services and its consequences for clinical research. Research is a cornerstone in addressing these challenges. Locally relevant evidence is crucial for informing healthcare policies and clinical guidelines, particularly in adapting high-income country recommendations to resource-constrained contexts. This review describes research challenges and findings on several fields of critical care in LMICs. It underscores the pressing need for sustained investment in critical care research and infrastructure in LMICs to overcome health disparities and improve outcomes for critically ill patients.",
  "authors": [
    {
      "affiliations": [
        "Critical Care, D’Or Institute for Research and Education, Rio de Janeiro, Rio de Janeiro, Brazil"
      ],
      "name": "Jorge I F Salluh"
    },
    {
      "affiliations": [
        "Critical Care, D’Or Institute for Research and Education, Rio de Janeiro, Rio de Janeiro, Brazil"
      ],
      "name": "Filipe Amado"
    },
    {
      "affiliations": [
        "Department of Precision-Regenerative Medicine and Jonic Area (DiMePRe-J), Section of Anesthesiology and Intensive Care Medicine, University of Bari \"Aldo Moro\", Bari, Italy",
        "Mahidol Oxford Tropical Research Unit (MORU), Bangkok, Thailand"
      ],
      "name": "Luigi Pisani"
    },
    {
      "affiliations": [
        "Critical Care, D’Or Institute for Research and Education, Rio de Janeiro, Rio de Janeiro, Brazil"
      ],
      "name": "Amanda Quintairos"
    },
    {
      "affiliations": [
        "Intensive Care, D'Or Institute for Research and Education, São Paulo, Brazil"
      ],
      "name": "Antonio Paulo Nassar, Jr"
    },
    {
      "affiliations": [
        "Intensive Care, D'Or Institute for Research and Education, São Paulo, Brazil"
      ],
      "name": "Bruno Besen"
    },
    {
      "affiliations": [
        "IDOR, Rio de Janeiro, Rio de Janeiro, Brazil"
      ],
      "name": "Cornelius Sendagire"
    },
    {
      "affiliations": [
        "Universidade de São Paulo, São Paulo, São Paulo, Brazil"
      ],
      "name": "Daniela C Souza"
    },
    {
      "affiliations": [
        "IDOR, Rio de Janeiro, Rio de Janeiro, Brazil"
      ],
      "name": "Fernando Bozza"
    },
    {
      "affiliations": [
        "Intensive Care Unit, Hospital Maciel, Montevideo, Montevideo, Uruguay"
      ],
      "name": "Gaston Burghi"
    },
    {
      "affiliations": [
        "The University of Edinburgh, Edinburgh, UK"
      ],
      "name": "Hem Raj Paneru"
    },
    {
      "affiliations": [
        "Department of Industrial Engineering (DEI), PUC-Rio, Rio de Janeiro, Rio de Janeiro, Brazil",
        "Tecgraf Institute, PUC-Rio, Rio de Janeiro, Rio de Janeiro, Brazil"
      ],
      "name": "Leonardo S L Bastos"
    },
    {
      "affiliations": [
        "Sociedad Argentina de Terapia Intensiva, Buenos Aires, Argentina"
      ],
      "name": "Maria del Pilar Arias López"
    },
    {
      "affiliations": [
        "IDOR, Rio de Janeiro, Rio de Janeiro, Brazil"
      ],
      "name": "Moses Siaw-Frimpong"
    },
    {
      "affiliations": [
        "IDOR, Rio de Janeiro, Rio de Janeiro, Brazil"
      ],
      "name": "Pedro Kurtz"
    },
    {
      "affiliations": [
        "Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil"
      ],
      "name": "Regis Goulart Rosa"
    },
    {
      "affiliations": [
        "AC Camargo Cancer Center, São Paulo, São Paulo, Brazil"
      ],
      "name": "Renato Daltro de Oliveira"
    },
    {
      "affiliations": [
        "Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil"
      ],
      "name": "Vanessa Soares Lanziotti"
    },
    {
      "affiliations": [
        "AC Camargo Cancer Center, São Paulo, São Paulo, Brazil"
      ],
      "name": "Juliana Carvalho Ferreira"
    },
    {
      "affiliations": [
        "Pulmonary Division, Heart Institute, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil",
        "London School of Hygiene & Tropical Medicine, London, UK"
      ],
      "name": "Otavio T Ranzani"
    }
  ],
  "title": "Critical care research in low- and middle-income countries: a narrative review",
  "uid": "7bf27e29-6f34-5df8-9f65-019e9fb2662d"
}