{
  "abstract": "Background Subglottic stenosis (SGS) is a rare condition with symptoms ranging from exertional breathlessness to severe airway compromise. Bronchoscopic intervention is typically the first-line intervention, with surgical resection considered in selected cases.Aims To review the prevalence of SGS in our region and our clinical experience in managing this condition, including complications, recurrence, and the outcomes of bronchoscopic interventions.Methods Retrospective analysis of 27 subglottic stenosis patients referred to adult respiratory service, in a large tertiary centre in UK between 2018 – 2025.Results The mean age was 48.8 (range 17 – 73) years with 24 (89%) female patients. 16 (59%) patients had idiopathic SGS, 6 (22%) were associated with granulomatosis with polyangiitis (GPA), and 5 (19%) were secondary to trauma or previous intubation. Excluding trauma, prevalence of SGS in our region is approximate 1/200,000. Most were never smokers, 4 had high BMI and 4 were diagnosed as having asthma.Diagnosis of SGS is made on bronchoscopic assessment, complemented by flow volume loops on spirometry. Tracheal biopsies during first procedure distinguishes idiopathic SGS from GPA. Extent of stenosis and distance from vocal cords are also recorded.Under general anaesthesia using rigid and flexible bronchoscope, graded balloon dilatation was performed in 13/16 (81%) idiopathic SGS, 4/6 (67%) GPA and 2/5 (40%) post traumatic patients. 7/19 (37%) required single dilatation and 12/19 (63%) experienced recurrence requiring multiple dilatations (range 2 – 5). Time to recurrence ranged from 2 months to 10 years. No serious complications or mortality were observed. Stenosis of >70% at presentation was associated with higher risk of recurrence. All patients were discussed in the regional multidisciplinary meeting and 3 patients underwent laryngo-tracheal resection for symptom relief.Abstract P208 Figure 1Conclusions Majority of SGS patients are females with no significant comorbidities. Combined rigid and flexible bronchoscopy with graded balloon dilatation is a safe minimally invasive procedure for the management of SGS, with no significant complications and avoids the need for invasive intervention in most cases. The recurrence rate is similar in patients with idiopathic SGS and those with GPA. Despite its rarity, SGS should be considered in patients presenting with unexplained exertional breathlessness.",
  "authors": [
    {
      "affiliations": [
        "University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK"
      ],
      "name": "HG Kamil"
    },
    {
      "affiliations": [
        "University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK"
      ],
      "name": "V Oakden"
    },
    {
      "affiliations": [
        "University Hospital Birmingham NHS Trust, Birmingham, UK"
      ],
      "name": "M Kalkat"
    },
    {
      "affiliations": [
        "University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK"
      ],
      "name": "M Haris"
    }
  ],
  "title": "P208 Sub-Glottic stenosis: a rare but clinically significant large airway disease – a single centre experience",
  "uid": "fe47ebc2-1347-5dcd-967a-a9902ecfc323"
}