{
  "abstract": "Introduction Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive, highly effective tool for evaluating mediastinal and hilar lymphadenopathy. While commonly used in lung cancer staging and diagnosis, EBUS also plays a diagnostic role in patients with unexplained mediastinal lymphadenopathy.Aims Understand the outcome of patients undergoing EBUS for mediastinal lymphadenopathy of uncertain cause.Methodology A retrospective audit was conducted of all EBUS-TBNA procedures performed between 2014 and 2024. Data were extracted from University Hospitals Plymouth NHS Trust EBUS database. Routinely, indication for EBUS is pre-categorised into 6 categories by the operator at the time of the procedure: These categories include: suspected lung cancer, suspected metastatic disease, isolated mediastinal lymphadenopathy of uncertain cause, cancer recurrence, research, and other. Histopathological findings were reviewed to assess diagnostic yield and disease distribution.Results During the audit period, 2343 EBUS were performed with 3891 samples taken, including suspected lung cancer (n=2463), suspected metastatic disease (n=376), isolated mediastinal lymphadenopathy of uncertain cause (n=923), cancer recurrence (n=86), research (n=2), and other (n=27).Of the 923 EBUS for mediastinal lymphadenopathy of uncertain cause, 463 (50%) were diagnosed with granulomatous inflammation consistent with sarcoidosis, 17(2%) had lymphoma, and 19(2%) had malignant diagnoses (e.g., NSCLC or SCLC). In contrast, among those with suspected lung cancer or metastatic disease, the diagnostic yield was dominated by malignancy (e.g., NSCLC adenocarcinoma: 543 cases; SCLC: 289 cases).Abstract P219 Table 1Conclusion In patients with mediastinal lymphadenopathy of unclear aetiology, most patients were diagnosed with sarcoidosis or had normal lymph node histology. The risk of lymphoma was <2%.",
  "authors": [
    {
      "affiliations": [
        "Plymouth University Hospitals Trust, Plymouth, UK"
      ],
      "name": "A Morozow"
    },
    {
      "affiliations": [
        "Royal Devon and Exeter Hospital, Exeter, Devon"
      ],
      "name": "J Corcoran"
    },
    {
      "affiliations": [
        "Plymouth University Hospitals Trust, Plymouth, UK"
      ],
      "name": "T Howell"
    },
    {
      "affiliations": [
        "Plymouth University Hospitals Trust, Plymouth, UK"
      ],
      "name": "A Iyer"
    },
    {
      "affiliations": [
        "Plymouth University Hospitals Trust, Plymouth, UK"
      ],
      "name": "T Nicholson"
    },
    {
      "affiliations": [
        "Plymouth University Hospitals Trust, Plymouth, UK"
      ],
      "name": "L Taylor"
    },
    {
      "affiliations": [
        "Plymouth University Hospitals Trust, Plymouth, UK"
      ],
      "name": "C Daneshvar"
    }
  ],
  "title": "P219 Ten year audit of endobronchial ultrasound (EBUS) biopsies: diagnostic yield and clinical indications (2014–2024)",
  "uid": "ecb0742a-d0f5-58ce-8bb9-e3f0e8dc40e6"
}