{
  "abstract": "Introduction The Apreo BREATHE Airway Scaffold is a self-expanding nitinol implant deployed via bronchoscopy to release trapped air. The effect of emphysema distribution and collateral ventilation (CV) on treatment response is unknown. Fissure integrity (FI) can be used as a non-invasive surrogate for CV.Aim To determine the impact of heterogeneity and FI on the treatment response of the BREATHE Airway Scaffold.Method In the first-in-human studies in Australia (BREATHE-1) and in Europe (BREATHE-2), up to three scaffolds were implanted per lung in 50 patients with severe hyperinflation bilaterally. Heterogeneous disease was defined as a ≥15% difference between upper and lower lobes at -910HU. Unilateral homogeneous included one homogeneous and one heterogenous lung. Complete fissures included a FI >95% in at least one lung. Changes in lung function tests, questionnaires and 6-minute walk distance (6MWD) were measured 6-months post treatment.Results All groups showed improvement in the outcomes at 6-months post treatment (mean±SEM).Those with at least one heterogenous lung had a greater improvement. FI did not have a significant impact on outcomes.Abstract P210 Table 1Conclusion The BREATHE Airway Scaffold may be an effective treatment for emphysema-related hyperinflation, including in those with bilateral incomplete fissures and homogenous emphysema; groups typically with limited options.",
  "authors": [
    {
      "affiliations": [
        "Royal Brompton Hospital and National Heart and Lung Institute, Imperial College, London, UK"
      ],
      "name": "A Tana"
    },
    {
      "affiliations": [
        "Karl Landsteiner Institute for Lung Research and Pulmonary Oncology, Klinik Floridsdorf, Vienna Health Care Group, Vienna, Austria"
      ],
      "name": "A Valipour"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia"
      ],
      "name": "A Ing"
    },
    {
      "affiliations": [
        "Department of Respiratory and Sleep Medicine, Royal Melbourne Hospital and Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Victoria, Australia"
      ],
      "name": "DP Steinfort"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital and National Heart and Lung Institute, Imperial College, London, UK"
      ],
      "name": "CM Orton"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital and National Heart and Lung Institute, Imperial College, London, UK"
      ],
      "name": "JL Garner"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital and National Heart and Lung Institute, Imperial College, London, UK"
      ],
      "name": "A Karir"
    },
    {
      "affiliations": [
        "Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, Netherlands"
      ],
      "name": "K Klooster"
    },
    {
      "affiliations": [
        "Karl Landsteiner Institute for Lung Research and Pulmonary Oncology, Klinik Floridsdorf, Vienna Health Care Group, Vienna, Austria"
      ],
      "name": "T Kleem"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia"
      ],
      "name": "JP Williamson"
    },
    {
      "affiliations": [
        "Department of Respiratory and Sleep Medicine, Royal Melbourne Hospital, Victoria, Australia"
      ],
      "name": "JJ Christie"
    },
    {
      "affiliations": [
        "Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, Netherlands"
      ],
      "name": "D Koster"
    },
    {
      "affiliations": [
        "Karl Landsteiner Institute for Lung Research and Pulmonary Oncology, Klinik Floridsdorf, Vienna Health Care Group, Vienna, Austria"
      ],
      "name": "K Welz"
    },
    {
      "affiliations": [
        "Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, Netherlands"
      ],
      "name": "M Van Dijk"
    },
    {
      "affiliations": [
        "Apreo Health, California, USA"
      ],
      "name": "SA Tuck"
    },
    {
      "affiliations": [
        "Apreo Health, California, USA"
      ],
      "name": "ML Mayse"
    },
    {
      "affiliations": [
        "Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, Netherlands"
      ],
      "name": "DJ Slebos"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital and National Heart and Lung Institute, Imperial College, London, UK"
      ],
      "name": "PL Shah"
    }
  ],
  "title": "P210 The impact of heterogeneity and fissure integrity on the treatment response of Airway Scaffolds for emphysema-related hyperinflation",
  "uid": "d47cbc13-e81a-5d69-bb73-a29eb951b56d"
}