{
  "abstract": "Introduction and Objectives Preliminary 1-year analyses from the real-world REALITI-A study demonstrated mepolizumab improvements in asthma control and lung function, a key outcome measurement, with mepolizumab treatment across blood eosinophil count (BEC) levels, in patients with severe asthma. However, additional real-world evidence on the sustained effect of mepolizumab across BEC ranges is required.Methods REALITI-A was a 2-year, international, observational, prospective, single-arm study enrolling patients (≥18 years) with severe asthma, newly prescribed mepolizumab (100 mg subcutaneously). Changes from baseline in asthma control (Asthma Control Questionnaire-5 [ACQ-5] scores, minimal clinically important difference: 0.5) and lung function (forced expiratory volume in 1 second [FEV 1]) were assessed for baseline BEC subgroups (<150, ≥150−<300, ≥300−<500, ≥500 cells/µL) at 1-year and 2-years post-mepolizumab exposure.Results 822 treated patients were included. ACQ-5 scores decreased from baseline to 2-years post-mepolizumab exposure across all BEC subgroups ( figure 1; mean change from baseline [95% CI]: <150 cells/µL, -1.40 [-3.27, 0.47]; ≥150−<300 cells/µL, -1.76 [-2.34, -1.19]; ≥300−<500 cells/µL, -1.74 [-2.15, -1.33]; ≥500 cells/µL, -1.88 [-2.23, -1.53]). Improvements in ACQ-5 were sustained from 1-year post-exposure reductions (mean change from baseline at 1-year [95% CI]: -1.06 [-1.68, -0.44]; -1.19 [-1.81, -0.57]; -1.37 [-1.84, -0.90]; -1.65 [-2.01, -1.28], respectively). Lung function (FEV1) improved from baseline to Month 21–24 post-mepolizumab exposure for the BEC ≥300 cells/µL subgroups (figure 1; mean change from baseline [95% CI]: ≥300−<500 cells/µL, 261.5 [111.1, 411.9]) and ≥500 cells/µL, 275.6 [160.5, 390.6]), sustained from changes in FEV1 at Month 9–12 post-exposure (mean change from baseline [95% CI]: 130.1 [-3.4, -263.7] and 239.4 [141.7, 337.2], respectively). Improvements in lung function were less consistent in the BEC groups <300 cells/µL.Abstract P199 Figure 1Asthma control improves and is sustained for 2 years for all BEC subgroups (left panel) and lung function improves and is sustained for 2 years for BEC ≥300 cells/uL subgroups (right panel). Error bars represent 95% CIConclusions This analysis confirms treatment with mepolizumab in a real-life setting improves asthma control independent of baseline BEC, while lung function shows greater improvement with increased BEC; improvements observed at 1 year are maintained at 2 years.",
  "authors": [
    {
      "affiliations": [
        "Department of Biomedical Sciences, Humanitas University, Milan, Italy"
      ],
      "name": "GW Canonica"
    },
    {
      "affiliations": [
        "Divisions of Allergy and Clinical Immunology, Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
      ],
      "name": "MC Liu"
    },
    {
      "affiliations": [
        "Department of Pulmonary Medicine, Cliniques Universitaires Saint-Luc, Brussels, Belgium"
      ],
      "name": "C Pilette"
    },
    {
      "affiliations": [
        "Department of Clinical Immunology and Allergy, Toronto Allergists, Toronto, ON, Canada"
      ],
      "name": "JK Lee"
    },
    {
      "affiliations": [
        "School of Infection and Immunity, University of Glasgow, Glasgow, UK"
      ],
      "name": "R Chaudhuri"
    },
    {
      "affiliations": [
        "Global Medical Affairs, Specialty Care, GSK, London, UK"
      ],
      "name": "S Gould"
    },
    {
      "affiliations": [
        "Biostatistics, GSK, Collegeville, PA, USA"
      ],
      "name": "L Zhang"
    },
    {
      "affiliations": [
        "Global Real-World Evidence and Health Outcomes Research, GSK, Collegeville, PA, USA"
      ],
      "name": "R Alfonso-Cristancho"
    },
    {
      "affiliations": [
        "Global Medical Affairs, Specialty Care, GSK, London, UK"
      ],
      "name": "P Howarth"
    }
  ],
  "title": "P199 Mepolizumab improves and sustains asthma control and lung function in patients with severe asthma independent of baseline blood eosinophil count in the real world: results from REALITI-A at 2 years",
  "uid": "a35e44db-5ca8-5d7e-b49c-ccdf0186d8b3"
}