{
  "abstract": "Background Chest radiographic consolidation is a marker of severe viral infection and a key factor in hospital management. Rates of consolidation and risk factors across RVI in adults remain poorly defined.Objectives To identify prevalence and clinical and laboratory predictors of consolidation in adults with RVI in a multi-centre UK study cohortMethods Analysis of the UNIVERSAL UK multicentre cohort of adults hospitalised with PCR-confirmed RVI. Admission chest radiographs were reviewed by clinical radiology staff and binarised for consolidation. Univariable and multivariable logistic regression were used to identify predictors.Results Between August 2022 and May 2025, 533 patients with RVI had chest radiography data. Consolidation was reported in 157/533 (29%) and was evenly distributed across viral groups (p = 0.170). Proportion with consolidation by viral group: influenza 32 (20%), SARS-CoV-2 52 (33%), RSV 21 (13%), rhino/enterovirus 29 (18%) and other viruses (Human metapneumovirus, coronaviruses, adenovirus and parainfluenza) 23 (15%).Median age was 70 (IQR 58–76) with consolidation versus 65 (IQR 53–76) without, p = 0.043. Consolidation was more common males 88/157 (56%) versus 161/376 (43%), p = 0.006 and in those vaccinated against pneumococcus 82/153 (54%) versus 144/370 (39%), p = 0.002.Consolidation was associated with ICU admission 10/156 (6.4%) versus 0/376 (0%), p < 0.001, oxygen requirement on admission 109/157 (69%) versus 205/375 (55%), p = 0.001, longer hospital stay (median 5 versus 4 days, p <0.001), and 60-day mortality 10/153 (6.5%) versus 8/365 (2.2%), p = 0.014. Median Charlson co-morbidity index was 9 (IQR 6–15) with consolidation versus 7 (IQR 4–12) without, p = 0.359.Median CRP and neutrophil-to-lymphocyte ratio (NLR) were higher with consolidation, CRP 113 versus 33 mg/L, NLR 9 versus 7, both p < 0.001.Multivariable analysis identified pneumococcal vaccination (OR 1.89, 95% CI 1.20–3.00, p = 0.006) and CRP >50 mg/L (OR 4.64, 95% CI 2.30–10.10, p < 0.001) as predictors of consolidation.Only 47/157 (30%) with consolidation had pneumonia listed as primary diagnosis on discharge (kappa = 0.265).Abstract P182 Table 1Characteristics of patients based on presence or absence of consolidation on chest radiographConclusion Consolidation was seen across RVIs and linked to inflammation and poor outcomes. Concordance with discharge diagnoses was limited, with possible implications for health economics.",
  "authors": [
    {
      "affiliations": [
        "Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK"
      ],
      "name": "M Purcell"
    },
    {
      "affiliations": [
        "University Hospital Southampton, Southampton, UK"
      ],
      "name": "M Darwish"
    },
    {
      "affiliations": [
        "Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK"
      ],
      "name": "T Morelli"
    },
    {
      "affiliations": [
        "Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK"
      ],
      "name": "A Mohammed"
    },
    {
      "affiliations": [
        "Southampton Clinical Trials Unit, University of Southampton, Southampton, UK"
      ],
      "name": "P Rodrigues"
    },
    {
      "affiliations": [
        "Southampton Clinical Trials Unit, University of Southampton, Southampton, UK"
      ],
      "name": "ABP Jones"
    },
    {
      "affiliations": [
        "Southampton Clinical Trials Unit, University of Southampton, Southampton, UK"
      ],
      "name": "PH Lee"
    },
    {
      "affiliations": [
        "Southampton Clinical Trials Unit, University of Southampton, Southampton, UK"
      ],
      "name": "KI Thorne"
    },
    {
      "affiliations": [
        "Southampton Clinical Trials Unit, University of Southampton, Southampton, UK"
      ],
      "name": "AP Allen"
    },
    {
      "affiliations": [
        "Institute for Lung Health, Department of Respiratory Sciences, University of Leicester, Leicester, UK"
      ],
      "name": "NJ Greening"
    },
    {
      "affiliations": [
        "Department of Respiratory Medicine, University Hospitals Sussex NHS Foundation Trust, Brighton and Haywards Heath, UK"
      ],
      "name": "M Pavitt"
    },
    {
      "affiliations": [
        "Department of Respiratory Medicine, University Hospitals Sussex NHS Foundation Trust, Brighton and Haywards Heath, UK"
      ],
      "name": "J Myerson"
    },
    {
      "affiliations": [
        "Cambridge University Hospitals NHS Trust, Cambridge, UK",
        "Royal Papworth Hospital, Cambridge, UK",
        "University of Cambridge, Cambridge, UK"
      ],
      "name": "SJ Marciniak"
    },
    {
      "affiliations": [
        "Department of Respiratory Medicine, Plymouth Hospitals NHS Trust, Plymouth, UK",
        "Faculty of Health, University of Plymouth, Plymouth, UK"
      ],
      "name": "C Daneshvar"
    },
    {
      "affiliations": [
        "Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK"
      ],
      "name": "MG Crooks"
    },
    {
      "affiliations": [
        "Department of Respiratory Medicine, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK"
      ],
      "name": "P Mitchelmore"
    },
    {
      "affiliations": [
        "Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK"
      ],
      "name": "JD Chalmers"
    },
    {
      "affiliations": [
        "National Heart and Lung Institute, Imperial College London, London, UK"
      ],
      "name": "S Siddiqui"
    },
    {
      "affiliations": [
        "Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK"
      ],
      "name": "TW Clark"
    },
    {
      "affiliations": [
        "Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK"
      ],
      "name": "A Freeman"
    },
    {
      "affiliations": [
        "Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK"
      ],
      "name": "T Wilkinson"
    }
  ],
  "title": "P182 Chest radiographic consolidation in adults hospitalised with respiratory viral infections (RVI): prevalence and predictors",
  "uid": "804c3741-6b41-51db-85e1-7bbbeaa93849"
}