{
  "abstract": "Introduction Admission to the intensive care unit (ICU) is deemed unfavourable for most patients with interstitial lung disease (ILD) who develop severe acute respiratory failure (SARF). Owing to the fulminant trajectory of their disease, individuals with new-onset ILD may have a particularly poor prognosis. This study compares ICU and post-discharge outcomes between patients with new-onset ILD and established ILD following admission for SARF.Methods Patients with ILD-related SARF and consecutively admitted to the adult ICU between 2009–2023 were included in this retrospective observational cohort study. New-onset ILD was defined as onset of ILD symptoms less than 6 months before ICU admission. Established ILD was thus defined as onset of ILD symptoms more than 6 months before ICU admission. Kaplan-Meier time-to-event analysis was censored at 12 months from ICU admission.Results Of 80 patients with ILD-SARF (55% male, median age 51 IQR 43–60), overall ICU mortality was 50%. Connective-Tissue Disease ILD (CTD-ILD), Idiopathic Interstitial Pneumonias (IIPs) and Exposure-Related ILD formed 40%, 28% and 10% of ILD subtypes diagnosed, respectively. 43 patients were transferred from secondary care. 50 were already intubated at admission. During admission, 64 patients received invasive mechanical ventilation (IMV), 23 received extracorporeal membrane oxygenation therapy (ECMO), and 30 received 2 or more immunosuppressive medications. Non-survivors in ICU had higher admission APACHE (p=0.026) and SOFA (p=0.018) scores, older age (OR 1.09, 95% CI 1.01–1.16), lower BMI (OR 0.84, 95% CI 0.72–0.98), and were more likely to receive IMV during admission (p=0.024). ICU mortality amongst new-onset ILD patients (n=33) was comparable to those with established ILD (n=47) (48% vs 51%, p= 0.82). New-onset ILD patients had a longer median length of ICU stay (25 vs 13 days, p=0.128) and time on IMV (29 vs 16 days, p=0.077). 1-year survival was higher in new-onset ILD patients (51% vs 36%, p=0.172).Abstract S154 Figure 1Conclusion Half the patients with ILD-associated SARF survived ICU admission at this specialist SARF/ILD centre. New-onset ILD patients had similar ICU survival to established ILD, with possibly better 1-year survival. Further data is being analysed for predicting ICU and post-discharge survival of patients with ILD-SARF treated at a SARF centre.",
  "authors": [
    {
      "affiliations": [
        "Imperial College London, London, UK"
      ],
      "name": "I Soo"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "TC Aw"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "M Gribbon"
    },
    {
      "affiliations": [
        "Chelsea and Westminster Hospital, London, UK"
      ],
      "name": "D Wiseman"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "M Kokosi"
    },
    {
      "affiliations": [
        "Imperial College London, London, UK"
      ],
      "name": "PL Molyneaux"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "E Renzoni"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "AU Wells"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "R Hewitt"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "V Kouranos"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "P George"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "J Alcada"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "M Passariello"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "J Dalton"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "B Garfield"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "B Patel"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "S Anwar"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "D Ransley"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "D Woods"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "J Doyle"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "K Bramley"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "A Brame"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "F Chua"
    },
    {
      "affiliations": [
        "Royal Brompton Hospital, London, UK"
      ],
      "name": "S Singh"
    }
  ],
  "title": "S154 Patients with new-onset interstitial lung disease (ILD) do not have higher mortality than those with established ILD when admitted to intensive care with severe acute respiratory failure (SARF)",
  "uid": "7cadb5b0-d0c9-5c00-8460-9f37ceff63c5"
}