{
  "abstract": "Introduction and Objectives Deprivation is strongly linked to COPD, exacerbations (ECOPD), hospitalisation and poor outcome. The non-invasive ventilation (NIV) outcomes score directed weaning trial (NIVOW: ISRCTN64639614) is a 7-centre RCT comparing two weaning regimes. We explored the impact of deprivation within the study population.Methods Deprivation was assessed using the Index of Multiple Deprivation (IMD) and distribution by decile captured from the most (IMD 1) to least (IMD 10) deprived. Univariate and independent associates were identified, and potential influence of deprivation on length of stay during the index admission (LoS), 30-day readmissions, secondary care review for COPD, and in-hospital and 90-day mortality explored.Results 84/164 (51.2%) participants were in decile 1–3, with 5.5 fold more participants in IMD 1 compared to IMD 10. Deprivation was associated with worse breathlessness and performance status eMRCD ( ρ =-0.59, p=0.01), but better pre-NIV pH (ρ= -8.9, p = 0.04) and pre-NIV PaCO2 (ρ =0.19, ρ= 0.05), with a trend for more frequent ECOPD within the previous 12 months (ρ= -0.14, p = 0.06). Substance use was uncommon, but more prevalent among the most deprived: 7/11 (63.6%) in the lowest 3 deciles. There was no significant difference in outcomes by deprivation decile.Abstract P124 Figure 1Conclusion Deprivation was strongly associated with ECOPD admissions requiring NIV across 7 UK centres. Higher deprivation was associated with worse breathlessness and performance status (eMRCD), and shows a trend toward increased exacerbation frequency. There was no association with FEV1% predicted, BMI, smoking or burden of comorbidities. More deprived participants had less severe respiratory acidaemia on admission which may reflect a less severe insult on a background of poorer performance status. Deprivation had no significant association with outcomes. Respiratory admissions in winter 2022/23 were 2.2 fold higher in IMD 1 (most deprived decile) compared to IMD 10. 1 In stark contrast there was a 5.5 fold difference in our population. There is an urgent need to address health inequalities in this large and disadvantaged population.Reference Breathing issues are the leading cause of all emergency admissions | Asthma + Lung UK",
  "authors": [
    {
      "affiliations": [
        "Northumbira Health Care NHS Foundation Trust, Newcastle Upon Tyne, UK",
        "Newcastle University, Newcastle Upon Tyne, UK"
      ],
      "name": "MH Naseer"
    },
    {
      "affiliations": [
        "Northumbira Health Care NHS Foundation Trust, Newcastle Upon Tyne, UK",
        "Northumbria University, Newcastle Upon Tyne, UK"
      ],
      "name": "K Brewin"
    },
    {
      "affiliations": [
        "Northumbria University, Newcastle Upon Tyne, UK"
      ],
      "name": "E Pakpahan"
    },
    {
      "affiliations": [
        "Northumbria University, Newcastle Upon Tyne, UK"
      ],
      "name": "J Gray"
    },
    {
      "affiliations": [
        "Northumbria University, Newcastle Upon Tyne, UK"
      ],
      "name": "S McCarthy"
    },
    {
      "affiliations": [
        "Northumbira Health Care NHS Foundation Trust, Newcastle Upon Tyne, UK",
        "Newcastle University, Newcastle Upon Tyne, UK"
      ],
      "name": "SC Bourke"
    }
  ],
  "title": "P124 Influence of deprivation on COPD patients with respiratory acidaemia requiring non-invasive ventilation",
  "uid": "77a6ef1f-5490-5d21-953a-7291649cf64e"
}