{
  "abstract": "Rationale The incidence of diabetes mellitus (DM) after hospitalisation with influenza in England is unknown.Objectives To establish the incidence of developing DM post hospitalisation with influenza using Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics (HES) in England.Methods Adults with a first episode of hospitalised influenza as the primary cause for admission between 01/07/2004 till 01/03/2021 based on ICD-10 codes without pre-existing DM were included. Patients were followed from one day after discharge till either DM diagnosis, death or end of GP record. A randomly selected group matched for age, sex and GP practice and an un-matched group of hospitalised sepsis patients were used as comparator groups. Missing data was imputed using multiple imputation model. Hazard ratios for outcome measures were calculated using Cox regression models and adjusted for potential confounders.Results 13,710 patients following influenza, 42.5% male, median age 57.6 (range 18 to 103) had a DM incidence of 12.5 per 1000 person years. Adjusted hazard ratios (aHR) for developing DM compared to non-hospitalised controls was 1.56 (95%CI 1.41–1.72, p<0.001) and to hospitalised sepsis comparators (1.12 (95% CI 1.02–1.24, p=0.023)). The greatest risk for developing DM in hospitalised influenza patients was within 90 days of discharge (aHR 2.80(95% CI 2.01–3.89), p<0.001) compared to non-hospitalised controls. Risk factors for DM included males, pre-existing DM risk, obesity and critical care admission during acute illness.Conclusion Patients hospitalised with influenza had a greater incidence of DM when compared to both matched controls and patients following hospitalisation with sepsis.",
  "authors": [
    {
      "affiliations": [
        "NIHR Nottingham Biomedical Research Centre, Nottingham, UK",
        "Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK",
        "Department of Respiratory Medicine, City Hospital, Nottingham University Hospital NHS Trust, Nottingham, UK"
      ],
      "name": "S Middleton"
    },
    {
      "affiliations": [
        "NIHR Nottingham Biomedical Research Centre, Nottingham, UK",
        "Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK"
      ],
      "name": "TM McKeever"
    },
    {
      "affiliations": [
        "Nottingham Centre for Epidemiology and Public Health, Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK"
      ],
      "name": "Y Huang"
    },
    {
      "affiliations": [
        "NIHR Nottingham Biomedical Research Centre, Nottingham, UK",
        "Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK",
        "Department of Respiratory Medicine, City Hospital, Nottingham University Hospital NHS Trust, Nottingham, UK"
      ],
      "name": "CE Bolton"
    }
  ],
  "title": "P185 Incidence of diabetes mellitus following hospitalisation with influenza",
  "uid": "699e5572-50e4-5fab-b492-19126f9f5340"
}