{
  "abstract": "Objectives The PREDICT-Meso International Accelerator Network (>150 investigators, 90 institutions, 16 countries) aims to define the biology driving Pleural Mesothelioma (PM). This requires assembly of a suitably characterised tissue resource spanning asbestos-associated pleural inflammation (AAPI)-to-PM evolution. The Meso-ORIGINS study is delivering this component, incorporating learning from a prior multi-centre feasibility trial where the PM evolution rate was 14% (95%CI 10.5–19.2). The primary objective is to collate longitudinal tissue pairs from patients with AAPI who evolve to PM. Secondary objectives are (a) generation of a multiomic risk prediction model for use in AAPI (b) characterisation of intra-patient tumour heterogeneity using multi-region thoracoscopic biopsies.Methods Meso-ORIGINS is a prospective multi-centre observational study, comprising two arms (A, which includes an MRI sub-study, & B). Arm A (target n=300) patients with histologically-confirmed AAPI undergo 6-monthly surveillance for 2 years, with clinical suspicion of PM evolution prompting repeat pleural biopsy and tissue banking. Arm A recruits also have baseline risk profiling via serum proteomics, exhaled breath metabolomics ± perfusion MRI. Arm B (target n=250) patients with suspected PM requiring thoracoscopy have multi-region thoracoscopic biopsies (aim 4–6/case).Results Recruitment opened in July 2022 and will end in August 2026. Across 25 UK sites (see figure 1), 408 patients have been recruited: 197/300 (66%) to Arm and 211/250 (84%) to Arm B. 18 PM evolutions (47% target) have been occurred in Arm A, where the current evolution rate is 11.3%, and the 95%CI overlaps with the prior feasibility study (7.3–17.4). 73/211 (35%) and 92/211 (44%) Arm B recruits have been diagnosed with PM and AAPI, respectively. 48/73 (66%) AAPI cases have subsequently been recruited to Arm A, permitting linkage of multi-region pre-PM biopsies. A mean (SD) of 3.9 (1.8) multi-region biopsies have been collected per Arm B case, generating 677 samples.Conclusions Meso-ORIGINS is generating a unique longitudinal, multi-region tissue resource spanning AAPI-to-PM evolution. This material is being processed in downstream PREDICT-Meso work-packages focused on multiomic target identification (including WES, spatial transcriptomics) and used for generation of new pre-clinical models and drug screening. Risk profiling results will inform eligibility criteria for future intervention trials for pre-PM patients.",
  "authors": [
    {
      "affiliations": [
        "University of Glasgow, Glasgow, UK"
      ],
      "name": "MDJ Neilly"
    },
    {
      "affiliations": [
        "Gartnavel General Hospital, Glasgow, UK"
      ],
      "name": "S Tsim"
    },
    {
      "affiliations": [
        "Glasgow Royal Infirmary, Glasgow, UK"
      ],
      "name": "J Maclay"
    },
    {
      "affiliations": [
        "Golden Jubilee National Hospital, Glasgow, UK"
      ],
      "name": "R Bilancia"
    },
    {
      "affiliations": [
        "Southmead Hospital, Bristol, UK"
      ],
      "name": "A Bibby"
    },
    {
      "affiliations": [
        "Royal Lancaster Infirmary, Morecambe, UK"
      ],
      "name": "T Gatheral"
    },
    {
      "affiliations": [
        "Royal Gwent Hospital, Newport, UK"
      ],
      "name": "A Ionescu"
    },
    {
      "affiliations": [
        "Grange University Hospital, Newport, UK"
      ],
      "name": "A Griffiths"
    },
    {
      "affiliations": [
        "Northumbria Specialist Emergency Care Hospital, Northumbria, UK"
      ],
      "name": "A Aujayeb"
    },
    {
      "affiliations": [
        "Oxford Respiratory Trials Unit, Churchill Hospital, Oxford, UK"
      ],
      "name": "N Rahman"
    },
    {
      "affiliations": [
        "Somerset Lung Centre, Musgrove Park Hospital, Somerset, UK"
      ],
      "name": "J Fallon"
    },
    {
      "affiliations": [
        "Wythenshawe Hospital, Manchester, UK"
      ],
      "name": "C Craig"
    },
    {
      "affiliations": [
        "Salford Royal Hospital, Salford, UK"
      ],
      "name": "M Macdougall"
    },
    {
      "affiliations": [
        "Derriford Hospital, Plymouth, UK"
      ],
      "name": "C Daneshvar"
    },
    {
      "affiliations": [
        "Glenfield Hospital, Leicester, UK"
      ],
      "name": "R Panchal"
    },
    {
      "affiliations": [
        "Glenfield Hospital, Leicester, UK"
      ],
      "name": "S Rajini"
    },
    {
      "affiliations": [
        "Aberdeen Royal Infirmary, Aberdeen, UK"
      ],
      "name": "M Chetty"
    },
    {
      "affiliations": [
        "Blackpool Teaching Hospital, Blackpool, UK"
      ],
      "name": "A Ashraf"
    },
    {
      "affiliations": [
        "Ninewells Hospital, Dundee, UK"
      ],
      "name": "P Short"
    },
    {
      "affiliations": [
        "Ninewells Hospital, Dundee, UK"
      ],
      "name": "K Ferguson"
    },
    {
      "affiliations": [
        "Raigmore Hospital, Inverness, UK"
      ],
      "name": "E Sage"
    },
    {
      "affiliations": [
        "Raigmore Hospital, Inverness, UK"
      ],
      "name": "L Allan"
    },
    {
      "affiliations": [
        "Southmead Hospital, Bristol, UK"
      ],
      "name": "R Crooks"
    },
    {
      "affiliations": [
        "Kettering General Hospital, Kettering, UK"
      ],
      "name": "R Reddy"
    },
    {
      "affiliations": [
        "University Hospital Monklands, Lanarkshire, UK"
      ],
      "name": "M Morrison"
    },
    {
      "affiliations": [
        "Western General Hospital, Edinburgh, UK"
      ],
      "name": "P Reid"
    },
    {
      "affiliations": [
        "Freeman Hospital, Newcastle, UK"
      ],
      "name": "A Stanton"
    },
    {
      "affiliations": [
        "University Hospital of North-Tees, North-Tees, UK"
      ],
      "name": "K Conroy"
    },
    {
      "affiliations": [
        "University Hospital of North-Tees, North-Tees, UK"
      ],
      "name": "B Purdon"
    },
    {
      "affiliations": [
        "Royal Papworth Hospital, Papworth, UK"
      ],
      "name": "L Succony"
    },
    {
      "affiliations": [
        "North General Hospital, Sheffield, UK"
      ],
      "name": "D DeFoneska"
    },
    {
      "affiliations": [
        "South Tyneside District Hospital, South Tyneside, UK"
      ],
      "name": "M Hashim"
    },
    {
      "affiliations": [
        "Royal Stoke University Hospital, Stoke, UK"
      ],
      "name": "M Haris"
    },
    {
      "affiliations": [
        "University of Glasgow, Glasgow, UK"
      ],
      "name": "J Roche"
    },
    {
      "affiliations": [
        "University of Glasgow, Glasgow, UK"
      ],
      "name": "A MacPherson"
    },
    {
      "affiliations": [
        "Cancer Research UK Beatson Institute, Glasgow, UK"
      ],
      "name": "L Alexander"
    },
    {
      "affiliations": [
        "Cancer Research UK Beatson Institute, Glasgow, UK"
      ],
      "name": "N Walker"
    },
    {
      "affiliations": [
        "Cancer Research UK Beatson Institute, Glasgow, UK"
      ],
      "name": "J Gourlay"
    },
    {
      "affiliations": [
        "Cancer Research UK Beatson Institute, Glasgow, UK"
      ],
      "name": "J McGarry"
    },
    {
      "affiliations": [
        "University of Glasgow, Glasgow, UK"
      ],
      "name": "K Blyth"
    }
  ],
  "title": "P163 An update regarding the meso-ORIGINS study: part of the PREDICT-meso international accelerator network",
  "uid": "105d271d-01c8-5bf2-b0a2-ad1dcb6bc556"
}