{
  "abstract": "Introduction Motor neurone disease (MND) is a progressive, degenerative, neuromuscular disorder. Patients with bulbar-onset present with swallowing and speaking abnormalities and have a worse prognosis.Aim To assess the upper airway function of patients living with MND (plwMND) using the forced oscillation technique (FOT).Methods Clinical assessment was performed in all patients. ALS Functional Rating Scale (ALSFRS-R) and the Sialorrhea scale were completed. Routine respiratory function testing, respiratory muscle assessment, and FOT were performed.Results Forty-eight plwMND (age=66.5±9.6 yrs, height1.65±0.11 m, BMI=25.9±4.1 kg·m -2) were included in the study (17 patients with bulbar-onset). FEV1, FVC, and FEV1/FVC were 86±29%pred., 86±26%pred., and 78±12%, respectively. TLC was 86±16%pred. and DLco was 74±21%pred. X5tot, X19tot, R5tot and R19tot were -1.27±1.35 cmH2O/(L/s), 0.53±0.59 cmH2O/(L/s), 3.79±1.64 cmH2O/(L/s), and 3.21±1.27 cmH2O/(L/s), respectively. ALSFSR-R was 34.9±8.1au and the Sialorrhea scale was 2.1±1.4au. Patients with bulbar-onset had significantly greater R5exp (4.95±2.31 cmH2O/(L/s)) and R19tot (3.80±1.69 cmH2O/(L/s)) than patients with limb-onset. Additionally, patients with bulbar-onset had significantly greater Sialorrhea score (3.0±1.3au) compared to limb-onset patients (1.6±1.2au). Overall, Sialorrhea score showed a correlation with R19exp (r=0.336, p=0.010), X5exp (r=-0.297, p=0.021) and X19exp (r=-0.395, p=0.003).Conclusion In plwMND, increased sialorrhea is associated with upper airway dysfunction which can be assessed by FOT.",
  "authors": [
    {
      "affiliations": [
        "Clinical Respiratory Physiology Centre, 1st University Department of Respiratory Medicine, ‘Sotiria’ Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"
      ],
      "name": "A Vontetsianos"
    },
    {
      "affiliations": [
        "Lane Fox Respiratory Service, Guy’s and St Thomas’ NHS Foundation Trust – Centre of Human and Applied Physiological Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK"
      ],
      "name": "N Shah"
    },
    {
      "affiliations": [
        "Clinical Respiratory Physiology Centre, 1st University Department of Respiratory Medicine, ‘Sotiria’ Hospital, Medical School, National and Kapodistrian University of Athens – Thorax Research Foundation, Athens, Greece"
      ],
      "name": "N Chynkiamis"
    },
    {
      "affiliations": [
        "Clinical Respiratory Physiology Centre, 1st University Department of Respiratory Medicine, ‘Sotiria’ Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"
      ],
      "name": "C Anagnostopoulou"
    },
    {
      "affiliations": [
        "Clinical Respiratory Physiology Centre, 1st University Department of Respiratory Medicine, ‘Sotiria’ Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"
      ],
      "name": "A Papasarantou"
    },
    {
      "affiliations": [
        "Clinical Respiratory Physiology Centre, 1st University Department of Respiratory Medicine, ‘Sotiria’ Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"
      ],
      "name": "G Stratakos"
    },
    {
      "affiliations": [
        "Clinical Respiratory Physiology Centre, 1st University Department of Respiratory Medicine, ‘Sotiria’ Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"
      ],
      "name": "P Bakakos"
    },
    {
      "affiliations": [
        "Clinical Respiratory Physiology Centre, 1st University Department of Respiratory Medicine, ‘Sotiria’ Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"
      ],
      "name": "N Koulouris"
    },
    {
      "affiliations": [
        "Clinical Respiratory Physiology Centre, 1st University Department of Respiratory Medicine, ‘Sotiria’ Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece",
        "Lane Fox Respiratory Service, Guy’s and St Thomas’ NHS Foundation Trust – Centre of Human and Applied Physiological Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK"
      ],
      "name": "G Kaltsakas"
    }
  ],
  "title": "P265 Forced oscillation technique indices are related to upper airway dysfunction in patients living with motor neurone disease (plwMND)",
  "uid": "0bac0c6e-0dcc-5f7e-84e7-0dacc616b01e"
}