{
  "abstract": "Background and aims Covert MRI markers of cerebral small vessel disease (CSVD) can coexist with large artery atherosclerosis. We aimed to explore whether the spatial distributions of these markers were diverse in people with or without intracranial artery stenosis (ICAS).Methods This cross-sectional analysis included 1206 stroke-free participants (aged 55.69±9.27, 62.94% female) with brain MRI and MR angiography from community-based Shunyi cohort. We analysed the relationships between ICAS and CSVD markers. We also compared the probability maps of lacunes, cerebral microbleeds (CMB), white matter hyperintensities (WMH) and cortex morphology at a voxel/vertex-wise level in groups with and without ICAS.Results ICAS increased the risk of lacunes by 2.99-fold (95% CI 1.99 to 4.50, p<0.001), lacunes ≥3 by 5.32 times (95% CI 2.76 to 10.28, p<0.001), correlated with WMH volume (β=0.332, SE=0.059, p<0.001), WMH Fazekas scores ≥5 (OR 4.50, 95% CI 2.44 to 8.29, p<0.001) and brain parenchymal fraction (β=−0.012, SE=0.002, p<0.001), but not with CMB. ICAS is associated with lacunes in the corresponding blood supply area. Lacunes that coexist with ICAS were prone in basal ganglia, while the lacunes without ICAS appeared in centrum semiovale more often. WMH with ICAS was prone to present in deep white matter involving the bilateral pyramidal tracts and superior thalamic radiation. People with ICAS were susceptible to worse cortical atrophy of right superior frontal and left rostral anterior cingulate. No obvious distributional differences were found for CMB between the two groups.Conclusions Since ICAS may be involved in the upstream pathogenesis of lacunes, white matter lesions and cortical atrophy, the impact of ICAS should not be ignored when evaluating MRI markers of CSVD.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurology, Peking Union Medical College Hospital, Beijing, China",
        "Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"
      ],
      "name": "Zi-Ang Pan"
    },
    {
      "affiliations": [
        "Department of Neurology, Peking Union Medical College Hospital, Beijing, China",
        "Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"
      ],
      "name": "Zi-Yue Liu"
    },
    {
      "affiliations": [
        "Department of Neurology, Peking Union Medical College Hospital, Beijing, China",
        "Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"
      ],
      "name": "Xing-Qi Pan"
    },
    {
      "affiliations": [
        "Department of Neurology, Peking Union Medical College Hospital, Beijing, China",
        "Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"
      ],
      "name": "Fei-Fei Zhai"
    },
    {
      "affiliations": [
        "Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China",
        "Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China"
      ],
      "name": "Ding-Ding Zhang"
    },
    {
      "affiliations": [
        "Department of Neurology, Peking Union Medical College Hospital, Beijing, China",
        "Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"
      ],
      "name": "Ming Yao"
    },
    {
      "affiliations": [
        "Department of Neurology, Peking Union Medical College Hospital, Beijing, China",
        "Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"
      ],
      "name": "Li-Xin Zhou"
    },
    {
      "affiliations": [
        "Department of Neurology, Peking Union Medical College Hospital, Beijing, China",
        "Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"
      ],
      "name": "Jun Ni"
    },
    {
      "affiliations": [
        "Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China",
        "Department of Radiology, Peking Union Medical College Hospital, Beijing, China"
      ],
      "name": "Zheng-Yu Jin"
    },
    {
      "affiliations": [
        "Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China",
        "Department of Cardiology, Peking Union Medical College Hospital, Beijing, China"
      ],
      "name": "Shu-Yang Zhang"
    },
    {
      "affiliations": [
        "Department of Neurology, Peking Union Medical College Hospital, Beijing, China",
        "Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"
      ],
      "name": "Li-Ying Cui"
    },
    {
      "affiliations": [
        "Department of Neurology, Peking Union Medical College Hospital, Beijing, China",
        "Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"
      ],
      "name": "Fei Han"
    },
    {
      "affiliations": [
        "Department of Neurology, Peking Union Medical College Hospital, Beijing, China",
        "Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"
      ],
      "name": "Yi-Cheng Zhu"
    }
  ],
  "title": "Characteristics of brain structural damage related to cerebral small vessel disease in general population with intracranial artery stenosis",
  "uid": "1c25109e-7018-5b3b-ba2d-6987842d40df"
}