{
  "abstract": "Rationale Neuroprotective strategies based on reperfusion therapy hold substantial promise for acute ischaemic stroke (AIS). Preclinical research indicates that tocilizumab, an interleukin-6 receptor antagonist, can attenuate ischaemia-reperfusion damage by exerting anti-inflammatory and neuroprotective effects.Aim To determine tocilizumab’s efficacy and safety when combined with endovascular thrombectomy (EVT) in patients with acute anterior circulation large vessel occlusion (LVO).Sample size estimates To determine a 30% decrease in average infarct core volume comparing the intervention and historical control groups (mean increase of 18.7 mL (SD=9.7 mL) post-thrombectomy) via a two-sided test (alpha=0.05, power=80%), accounting for a 10% drop-out rate, we plan to recruit 108 participants.Methods and design This trial is designed as a randomised, multicentre, double-blind, placebo-controlled trial. Patients will be randomly and evenly allocated to the tocilizumab or placebo groups.Study outcomes The primary endpoint is the change in infarct core volume between baseline and 72 hours post-treatment. Secondary outcomes include the 90-day modified Rankin scale score (0–2, indicating functional independence). The key safety endpoints include 90-day mortality and symptomatic intracerebral haemorrhage within 72 hours after EVT.Discussion Administering tocilizumab within 24 hours of stroke as an adjunct to EVT may effectively reduce the infarct core volume for patients experiencing AIS with anterior circulation LVO, potentially improving functional outcomes in these patients.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China"
      ],
      "name": "Xuehong Chu"
    },
    {
      "affiliations": [
        "Department of Neurology, Suzhou Municipal Hospital of Anhui Province, Suzhou, Anhui, China"
      ],
      "name": "Zhengfei Ma"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanyang Central Hospital, Nanyang, Henan, China"
      ],
      "name": "Yifeng Liu"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanyang Central Hospital, Nanyang, Henan, China"
      ],
      "name": "Jun Sun"
    },
    {
      "affiliations": [
        "Department of Neurology, Nanyang Central Hospital, Nanyang, Henan, China"
      ],
      "name": "Ning Wang"
    },
    {
      "affiliations": [
        "Department of Neurology, Xihua County People's Hospital, Zhoukou, Henan, China"
      ],
      "name": "Chaoqun Li"
    },
    {
      "affiliations": [
        "Department of Neurology, Xihua County People's Hospital, Zhoukou, Henan, China"
      ],
      "name": "Xiangyang Feng"
    },
    {
      "affiliations": [
        "Department of Neurology, Sui Xi County Hospita, Anhui Province, China"
      ],
      "name": "Jianqiao Li"
    },
    {
      "affiliations": [
        "Anhui Wanbei Coal Electricity Group General Hospital, Suzhou, China"
      ],
      "name": "Benxiao Wang"
    },
    {
      "affiliations": [
        "Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China"
      ],
      "name": "Chen Zhou"
    },
    {
      "affiliations": [
        "Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China"
      ],
      "name": "Chuanhui Li"
    },
    {
      "affiliations": [
        "Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China"
      ],
      "name": "Wenbo Zhao"
    },
    {
      "affiliations": [
        "Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China"
      ],
      "name": "Xunming Ji"
    },
    {
      "affiliations": [
        "Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China"
      ],
      "name": "Chuanjie Wu"
    }
  ],
  "title": "IRIS, a randomised, double-blind, placebo-controlled trial of interleukin-6 receptor inhibition undergoing endovascular treatment in acute anterior circulation ischaemic stroke: study rationale and design",
  "uid": "7eadc64c-94ea-5695-b22e-ca0a144d1e2e"
}