{
  "abstract": "Background and purpose To date, no large cohort study has investigated the effects of intravenous thrombolysis (IVT) in Chinese patients aged over 80 years who had a stroke. This study aimed to assess the trends in the use of alteplase, the clinical characteristics and the outcomes of Chinese patients aged above 80 years who had an acute ischaemic stroke.Methods Data for this analysis were obtained from the China Stroke Center Alliance programme, a nationwide, multicentre, prospective registry encompassing 1751 hospitals across 31 provinces, covering the period from 1 January 2018 to 14 December 2022. The primary outcome was defined as a modified Rankin Scale (mRS) Score of 0–2 at discharge. Secondary outcomes included an mRS Score of 0–1 and independent ambulation on discharge. Safety outcomes assessed were in-hospital mortality and symptomatic intracranial haemorrhage (sICH).Results Out of 30 902 patients over 80 years old who qualified for thrombolysis, 8673 (median age (IQR), 84 (82–87) years) received alteplase treatment. Patients administered alteplase demonstrated improved short-term functional outcomes, such as an mRS Score of 0–2 (adjusted OR (aOR) 1.12, 95% CI, 1.06 to 1.18, p<0.001), an mRS Score of 0–1 (aOR 1.14, 95% CI, 1.08 to 1.19, p<0.001) and independent ambulation at discharge (aOR 1.14, 95% CI, 1.08 to 1.20, p<0.001). Moreover, no significant increase was observed in the risk of in-hospital mortality (aOR 1.12, 95% CI, 0.93 to 1.35; p=0.23). However, the risk of sICH was significantly higher among patients treated with alteplase (aOR 3.22, 95% CI, 2.77 to 3.75; p<0.001).Conclusions IVT with alteplase in elderly patients who had a stroke resulted in improved short-term functional outcomes without elevating the risk of in-hospital mortality. Nonetheless, this population remains at a higher risk of sICH.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurology, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China",
        "Department of Emergency, Taihe Hospital,Hubei University of Medicine, Shiyan, Hubei, China",
        "China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China"
      ],
      "name": "Changsheng Li"
    },
    {
      "affiliations": [
        "Department of Neurology, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China",
        "China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China",
        "National Center for Healthcare Quality Management in Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China"
      ],
      "name": "Yingyu Jiang"
    },
    {
      "affiliations": [
        "Department of Neurology, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China",
        "China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China",
        "National Center for Healthcare Quality Management in Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China"
      ],
      "name": "Hong-Qiu Gu"
    },
    {
      "affiliations": [
        "Department of Neurology, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China",
        "China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China",
        "National Center for Healthcare Quality Management in Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China"
      ],
      "name": "Meng Wang"
    },
    {
      "affiliations": [
        "Department of Neurology, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China",
        "China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China"
      ],
      "name": "Zimo Chen"
    },
    {
      "affiliations": [
        "China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China",
        "National Center for Healthcare Quality Management in Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China"
      ],
      "name": "Xin Yang"
    },
    {
      "affiliations": [
        "China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China"
      ],
      "name": "Qi Zhou"
    },
    {
      "affiliations": [
        "Department of Neurology, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China",
        "China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China"
      ],
      "name": "Xia Meng"
    },
    {
      "affiliations": [
        "Department of Neurology, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China",
        "China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China",
        "National Center for Healthcare Quality Management in Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China"
      ],
      "name": "Chunjuan Wang"
    },
    {
      "affiliations": [
        "Department of Neurology, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China",
        "China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China",
        "National Center for Healthcare Quality Management in Neurological Diseases, Beijing Tiantan Hospital,Capital Medical University, Fengtai, Beijing, China"
      ],
      "name": "Zixiao Li"
    }
  ],
  "title": "Characteristics, temporal trends and outcomes of intravenous thrombolysis in Chinese patients aged>80 years who had a stroke",
  "uid": "57bb7c00-aedc-5bc9-9f62-08e0aad2d13a"
}