{
  "abstract": "Introduction The incidence of cancer-associated ischaemic stroke (IS) is increasingly prevalent. This study aimed to assess the levels of enlarged perivascular spaces in basal ganglion (BG-EPVS) in cancer-associated patients who had a stroke compared with the control group, and to investigate the diagnostic utility of BG-EPVS in the context of cancer-associated stroke.Method A matched case–control study was conducted in Xiamen, China. A total of 184 IS patients (cancer vs control=1:1) were recruited. The severity of BG-EPVS was graded using high-resolution MRI. Patients’ gender, age, clinical risk factors, other imaging changes and laboratory findings information at admission were collected. Logistic regression models were constructed and subgroup analysis by cancer treatment.Result Overall, 65.22% of the 184 subjects were male, with a mean (SD) age of 68.83±10.52 years. BG-EPVS had a significant influence on cancer-associated stroke (OR=1.85 (95% CI 1.29, 2.71), p=0.001) after adjusting for gender, age, clinical risk factors, other imaging changes and laboratory findings. The area under the curve of the diagnosis model that combined BG-EPVS and other factors was 0.848 (95% CI 0.787, 0.896), significantly higher than the other three models. Subgroup analysis suggested a heightened association between BG-EPVS and cancer-associated stroke within the cancer treatment group.Conclusion In conclusion, this is the first study to assess the diagnosis values of BG-EPVS on cancer-associated stroke and helps us understand the pathogenesis of cancer-associated stroke. Our findings demonstrate the effectiveness of BG-EPVS in diagnosing IS patients who may carry underlying cancer.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China",
        "National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China"
      ],
      "name": "Jielong Wu"
    },
    {
      "affiliations": [
        "Cerebrovascular Interventional Department, Zhangzhou Hospital of Fujian Province, Zhangzhou, Fujian, China",
        "The School of Clinical Medicine, Fujian Medical University, Fuzhou, China"
      ],
      "name": "Ganji Hong"
    },
    {
      "affiliations": [
        "Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China",
        "The School of Clinical Medicine, Fujian Medical University, Fuzhou, China",
        "Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China",
        "Xiamen Key Laboratory of Brain Center, Xiamen, China",
        "Xiamen Medical Quality Control Center for Neurology, Xiamen, China",
        "Fujian Provincial Clinical Research Center for Brain Diseases, Xiamen, China",
        "Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China"
      ],
      "name": "Liangcheng Zheng"
    },
    {
      "affiliations": [
        "Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China",
        "The School of Clinical Medicine, Fujian Medical University, Fuzhou, China"
      ],
      "name": "Jiedong Zhao"
    },
    {
      "affiliations": [
        "Department of Neurology, Xiamen Susong Hospital, Xiamen, China"
      ],
      "name": "Lu Yu"
    },
    {
      "affiliations": [
        "Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China",
        "The School of Clinical Medicine, Fujian Medical University, Fuzhou, China",
        "Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China",
        "Xiamen Key Laboratory of Brain Center, Xiamen, China",
        "Xiamen Medical Quality Control Center for Neurology, Xiamen, China",
        "Fujian Provincial Clinical Research Center for Brain Diseases, Xiamen, China",
        "Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China"
      ],
      "name": "Chuya Jing"
    },
    {
      "affiliations": [
        "Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China",
        "The School of Clinical Medicine, Fujian Medical University, Fuzhou, China",
        "Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China",
        "Xiamen Key Laboratory of Brain Center, Xiamen, China",
        "Xiamen Medical Quality Control Center for Neurology, Xiamen, China",
        "Fujian Provincial Clinical Research Center for Brain Diseases, Xiamen, China",
        "Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China"
      ],
      "name": "Qiuhong Zhang"
    },
    {
      "affiliations": [
        "Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China",
        "The School of Clinical Medicine, Fujian Medical University, Fuzhou, China",
        "Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China",
        "Xiamen Key Laboratory of Brain Center, Xiamen, China",
        "Xiamen Medical Quality Control Center for Neurology, Xiamen, China",
        "Fujian Provincial Clinical Research Center for Brain Diseases, Xiamen, China",
        "Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China"
      ],
      "name": "Chen Wang"
    },
    {
      "affiliations": [
        "Department of Gynecology of Xiamen Maternal and Child Health Care Hospital, Xiamen, China",
        "The Graduate School of Fujian Medical University, Fuzhou, China"
      ],
      "name": "Xiaodong Yuan"
    },
    {
      "affiliations": [
        "Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China",
        "The School of Clinical Medicine, Fujian Medical University, Fuzhou, China",
        "Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China",
        "Xiamen Key Laboratory of Brain Center, Xiamen, China",
        "Xiamen Medical Quality Control Center for Neurology, Xiamen, China",
        "Fujian Provincial Clinical Research Center for Brain Diseases, Xiamen, China",
        "Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China"
      ],
      "name": "Qing Lin"
    },
    {
      "affiliations": [
        "National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China",
        "Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China",
        "Xiamen Key Laboratory of Brain Center, Xiamen, China",
        "Xiamen Medical Quality Control Center for Neurology, Xiamen, China",
        "Fujian Provincial Clinical Research Center for Brain Diseases, Xiamen, China",
        "Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China",
        "Department of Neurosurgery and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China",
        "Fujian University of Traditional Chinese Medicine, Fuzhou, China"
      ],
      "name": "Zhanxiang Wang"
    },
    {
      "affiliations": [
        "Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China",
        "National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China",
        "The School of Clinical Medicine, Fujian Medical University, Fuzhou, China",
        "Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China",
        "Xiamen Key Laboratory of Brain Center, Xiamen, China",
        "Xiamen Medical Quality Control Center for Neurology, Xiamen, China",
        "Fujian Provincial Clinical Research Center for Brain Diseases, Xiamen, China",
        "Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China",
        "The Graduate School of Fujian Medical University, Fuzhou, China",
        "Fujian University of Traditional Chinese Medicine, Fuzhou, China"
      ],
      "name": "Qilin Ma"
    },
    {
      "affiliations": [
        "Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China",
        "The School of Clinical Medicine, Fujian Medical University, Fuzhou, China",
        "Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen, China",
        "Xiamen Key Laboratory of Brain Center, Xiamen, China",
        "Xiamen Medical Quality Control Center for Neurology, Xiamen, China",
        "Fujian Provincial Clinical Research Center for Brain Diseases, Xiamen, China",
        "Xiamen Clinical Research Center for Neurological Diseases, Xiamen, China",
        "The Graduate School of Fujian Medical University, Fuzhou, China",
        "Fujian University of Traditional Chinese Medicine, Fuzhou, China"
      ],
      "name": "Jie Fang"
    }
  ],
  "title": "Correlation of enlarged perivascular spaces in basal ganglion and cancer-associated stroke: a case–control study in China",
  "uid": "353d18b1-04e4-5f66-9342-051fac8127aa"
}