{
  "abstract": "Background With increased life expectancy of people living with HIV (PLWH), non-AIDS-defining cancers (NADCs) represent a major cause of cancer-related morbidity and mortality. Among these, cancers with effective screening strategies are key targets for prevention, yet real-world data on screening uptake in PLWH remain limited. The aim of the study was to evaluate the gap between the 2023 European AIDS Clinical Society (EACS) Guidelines and clinical practice.Methods This single-centre retrospective study included PLWH aged ≥18 years actively followed at the Modena HIV Clinic (Modena, Italy) between January 1st, 2023, and December 31st, 2025. Electronic charts and radiology records were reviewed to identify lung CT scans among individuals eligible per EACS 2023 criteria: current or former smokers (quit <15 years), age between 50–80 years, pack-years >20. Adherence was defined as CT execution during the study period: none (no CT performed ever), partial (one CT), or full (≥2 CTs). Socio-demographic, behavioural, HIV-related, and cancer-related variables (including biopsy and results) were collected. Descriptive analyses were performed by adherence category.Results Preliminary data include 405 former (N=174) or current smokers (N=231). Among former smokers, 29% were eligible (N=46), while 71% of current smokers met criteria (N=113). In the eligible group (N=159), male-to-female ratio was 4:1 (120 vs 39), mean age 61 years (IQR 58–65), mean HIV duration 32 years (IQR 22–39), and mean CD4+ nadir 221/ml (IQR 110–327). HIV-RNA was undetectable in 99% (N=156); mean pack-years was 37 (IQR 28–43). Socio-demographic characteristic and HIV-related variables were stratified for adherence, as shown in table 1.Of the 159 eligible individuals, 113 (71%) had no adherence, 39 (25%) partial adherence, and 7 (4%) full adherence. Adherence was higher in individuals with shorter HIV duration (p=0.006). CT results were negative in 26 (56%) cases. Nodules >1cm, <1cm, and multiple micronodules were detected in 9 (19%), 5 (11%), and 4 (8.7%) cases, respectively. Biopsy was performed in 4 cases, confirming 3 lung cancers. Screening uptake and results were described as a cascade of care model in figure 1. Additionally, 18 (11%) individuals underwent lung CT scan for other reasons; 7 showed nodules/micronodules and 2 biopsies were positive for malignancy.Conclusion These preliminary findings confirm the importance of lung cancer screening in PLWH. A not negligible gap exists between guidelines recommendation and clinical practice in CT execution, that in our population was not guided by specific behavioural or socio-demographic determinants. A major effort should be done integrating risk algorithms and screening programs within routine clinical practice to allow earlier and proactive diagnosis of lung cancer.Abstract P50 Figure 1Cascade of care model of screening uptake and results in our cohortAbstract P50 Table 1Socio-demographic characteristics, HIV-related variables, and smoking habits of eligible individuals, stratified by adherence",
  "authors": [
    {
      "affiliations": [
        "Infectious Diseases Clinic, University of Modena and Reggio Emilia, Modena, Italy"
      ],
      "name": "F Calandra Buonaura"
    },
    {
      "affiliations": [
        "Infectious Diseases Clinic, University of Modena and Reggio Emilia, Modena, Italy"
      ],
      "name": "E Delmonte"
    },
    {
      "affiliations": [
        "Infectious Diseases Clinic, University of Modena and Reggio Emilia, Modena, Italy"
      ],
      "name": "F Prandini"
    },
    {
      "affiliations": [
        "Infectious Diseases Clinic, University of Modena and Reggio Emilia, Modena, Italy"
      ],
      "name": "U Calvi"
    },
    {
      "affiliations": [
        "Infectious Diseases Clinic, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy"
      ],
      "name": "A Cervo"
    },
    {
      "affiliations": [
        "Infectious Diseases Clinic, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy"
      ],
      "name": "G Cuomo"
    },
    {
      "affiliations": [
        "Infectious Diseases Clinic, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy"
      ],
      "name": "M Menozzi"
    },
    {
      "affiliations": [
        "Infectious Diseases Clinic, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy"
      ],
      "name": "C Mussini"
    }
  ],
  "title": "P50 From guidelines to clinical practice: lung cancer screening adherence, preliminary data from the modena HIV cohort",
  "uid": "9c992b32-70dc-58da-b82a-7913cd6f1661"
}