{
  "abstract": "Background The long-acting (LA) treatment with cabotegravir (CAB) and rilpivirine (RPV) has been reported to have a neutral effect on weight and blood lipids in people with HIV (PWH) during treatment. However, few real-world data are available from observational cohorts.Materials and Methods This was a multicentre prospective observational study conducted within the SCOLTA (Surveillance Cohort Long-Term Toxicity Antiretrovirals) project. PWH RNA<50 copies/mL switched to CAB+RPV LA from 2022 onwards with at least one year of follow-up were included. Variables were compared using the paired t-test (1- and 2-years vs baseline). To determine the association between change from baseline and PWH’s characteristics, we run a multivariate model including age, sex, BMI, CD4-T cells and the baseline value of the variable.Results A total of 671 PWH were enrolled, with a median follow-up period of 22 months (interquartile range, IQR: 13–29 months). The median age of the participants was 49 years (IQR 40–58) and median duration of ART was 10.3 years (IQR 6.4–16.7). The median body mass index (BMI) at enrolment was 24.6 kg/m 2 (IQR 22.6–27.0).During the follow-up, mean weight did not change significantly in the study population, with a change of -0.25 kg (95% CI: -0.59 to +0.08, p = 0.1403) after one year and -0.18 kg (95% CI: -0.70 to +0.33, p = 0.4864) after two years. The multivariable analysis revealed that the probability of weight change was significantly associated with baseline BMI, with obese people experiencing a reduction in weight, significantly greater compared to normal-weight (mean estimate -2.79 kg, SE 0.64, p<0.0001), and those who were overweight showed a tendency towards significant reduction (mean estimate -0.75 kg, SE 0.38, p=0.052; see figure 1). Age, sex and CD4 count did not correlate with the probability of weight change.Regarding blood lipids, LDL levels remained stable during the study, while total cholesterol increased significantly, driven by an increase in HDL levels (table 1).Multivariable analysis revealed that trends in total cholesterol, HDL and LDL cholesterol were inversely correlated with their baseline values (mean estimated change: -0.36 ± SE 0.04, p <.0001; -0.39 ± SE 0.05, p <0.0001; and -0.38 ± SE 0.04, p <0.0001, respectively). HDL changes also showed a direct linear correlation with female sex (estimate: +4.02 ± SE 1.60, p = 0.0123) and age (estimate: +0.12 ± SE 0.05, p = 0.0322).Conclusions Body weight remained stable in SCOLTA after switching to LA CAB+RPV during two-years of observation. People with higher BMI at baseline were more likely to lose weight during treatment, confirming the feasibility of this regimen also in obese people and reassuring towards the concern of further weight gain and the consequent difficulty of achieving the proper injection depth. The modest but significant increase in cholesterol levels was driven by an increase in HDL, confirming the metabolic safety of the LA regimen.Abstract SC19 Table 1Metabolic Parameters at Baseline and During Follow-Up After Switch to LA CAB+RPVAbstract SC19 Figure 1Mean weight change over time by BMI category",
  "authors": [
    {
      "affiliations": [
        "Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy"
      ],
      "name": "G Cologgi"
    },
    {
      "affiliations": [
        "Infectious Diseases Unit, IRCCS Azienda Ospedaliera Metropolitana, Genova, Italy"
      ],
      "name": "L Taramasso"
    },
    {
      "affiliations": [
        "Fondazione ASIA, Milan, Italy"
      ],
      "name": "E Ricci"
    },
    {
      "affiliations": [
        "Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy"
      ],
      "name": "S Ferrara"
    },
    {
      "affiliations": [
        "Unit of Infectious Diseases, Divisione A, Amedeo di Savoia Hospital, Torino, Italy"
      ],
      "name": "G Orofino"
    },
    {
      "affiliations": [
        "Infectious Disease Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza - University of Milano-Bicocca, Monza, Italy"
      ],
      "name": "N Squillace"
    },
    {
      "affiliations": [
        "Department of Infectious Diseases, Galliera Hospital, Genoa, Italy"
      ],
      "name": "E Pontali"
    },
    {
      "affiliations": [
        "Unit of Infectious Diseases, ASST della Valle Olona – Busto Arsizio (VA), Italy"
      ],
      "name": "B Menzaghi"
    },
    {
      "affiliations": [
        "Infectious Diseases Unit, SS. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy"
      ],
      "name": "E Sarchi"
    },
    {
      "affiliations": [
        "Infectious Diseases Department, Sanremo Hospital, Sanremo, Italy"
      ],
      "name": "G Cenderello"
    },
    {
      "affiliations": [
        "Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"
      ],
      "name": "G Pellicanò"
    },
    {
      "affiliations": [
        "Unit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, Italy"
      ],
      "name": "G Madeddu"
    },
    {
      "affiliations": [
        "Unit of Infectious Diseases, San Paolo Hospital, Milano, Italy"
      ],
      "name": "T Bini"
    },
    {
      "affiliations": [
        "AOU Infectious and Tropical Diseases, Careggi Hospital, Florence, Italy"
      ],
      "name": "F Lagi"
    },
    {
      "affiliations": [
        "Unit of Infectious Diseases, Ospedale Maggiore della Carità, Novara, Italy"
      ],
      "name": "O Bargiacchi"
    },
    {
      "affiliations": [
        "Infectious Diseases and Gender Medicine Unit, Cotugno Hospital, AO dei Colli, Naples, Italy"
      ],
      "name": "M Carleo"
    },
    {
      "affiliations": [
        "SOC 1 USL CENTRO FIRENZE, Unit of Infectious Diseases, Santa Maria Annunziata Hospital, Florence, Italy"
      ],
      "name": "E Salomoni"
    },
    {
      "affiliations": [
        "Infectious Diseases Unit, Ospedale S. Anna, Como, Italy"
      ],
      "name": "L Pusterla"
    },
    {
      "affiliations": [
        "Infectious Diseases Unit, IRCCS Policlinico Sant’Orsola, University of Bologna, Italy"
      ],
      "name": "L Calza"
    },
    {
      "affiliations": [
        "Infectious Diseases Unit, ASST Ovest Milanese, Legnano and DIBIC, University of Milan, Italy"
      ],
      "name": "S Rusconi"
    },
    {
      "affiliations": [
        "Clinic of Infectious Diseases, Department of Medicine and Science of Aging, G. d’Annunzio University, Chieti-Pescara, Chieti, Italy"
      ],
      "name": "K Falasca"
    },
    {
      "affiliations": [
        "Department of Infectious Diseases, University of Campania Luigi Vanvitelli, Naples, Italy"
      ],
      "name": "S Martini"
    },
    {
      "affiliations": [
        "Clinical and Research Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy"
      ],
      "name": "R Bellagamba"
    },
    {
      "affiliations": [
        "Unit of Infectious Diseases, A. Manzoni Hospital, Lecco, Italy"
      ],
      "name": "S Piconi"
    },
    {
      "affiliations": [
        "Infectious Diseases Clinic, Department of Medicine and Surgery, University of Perugia, Italy"
      ],
      "name": "G De Socio"
    },
    {
      "affiliations": [
        "Infectious Diseases Unit, SS Trinità Hospital, Cagliari, Italy"
      ],
      "name": "G Angioni"
    },
    {
      "affiliations": [
        "Unit of Infectious Diseases, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy"
      ],
      "name": "A Cascio"
    },
    {
      "affiliations": [
        "Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy",
        "Infectious Diseases Unit, IRCCS Azienda Ospedaliera Metropolitana, Genova, Italy"
      ],
      "name": "A Di Biagio"
    },
    {
      "affiliations": [
        "Infectious Disease Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza - University of Milano-Bicocca, Monza, Italy"
      ],
      "name": "P Bonfanti"
    },
    {
      "affiliations": [
        "Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy",
        "Infectious Diseases Unit, IRCCS Azienda Ospedaliera Metropolitana, Genova, Italy",
        "Fondazione ASIA, Milan, Italy",
        "Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy",
        "Unit of Infectious Diseases, Divisione A, Amedeo di Savoia Hospital, Torino, Italy",
        "Infectious Disease Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza - University of Milano-Bicocca, Monza, Italy",
        "Department of Infectious Diseases, Galliera Hospital, Genoa, Italy",
        "Unit of Infectious Diseases, ASST della Valle Olona – Busto Arsizio (VA), Italy",
        "Infectious Diseases Unit, SS. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy",
        "Infectious Diseases Department, Sanremo Hospital, Sanremo, Italy",
        "Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy",
        "Unit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, Italy",
        "Unit of Infectious Diseases, San Paolo Hospital, Milano, Italy",
        "AOU Infectious and Tropical Diseases, Careggi Hospital, Florence, Italy",
        "Unit of Infectious Diseases, Ospedale Maggiore della Carità, Novara, Italy",
        "Infectious Diseases and Gender Medicine Unit, Cotugno Hospital, AO dei Colli, Naples, Italy",
        "SOC 1 USL CENTRO FIRENZE, Unit of Infectious Diseases, Santa Maria Annunziata Hospital, Florence, Italy",
        "Infectious Diseases Unit, Ospedale S. Anna, Como, Italy",
        "Infectious Diseases Unit, IRCCS Policlinico Sant’Orsola, University of Bologna, Italy",
        "Infectious Diseases Unit, ASST Ovest Milanese, Legnano and DIBIC, University of Milan, Italy",
        "Clinic of Infectious Diseases, Department of Medicine and Science of Aging, G. d’Annunzio University, Chieti-Pescara, Chieti, Italy",
        "Department of Infectious Diseases, University of Campania Luigi Vanvitelli, Naples, Italy",
        "Clinical and Research Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy",
        "Unit of Infectious Diseases, A. Manzoni Hospital, Lecco, Italy",
        "Infectious Diseases Clinic, Department of Medicine and Surgery, University of Perugia, Italy",
        "Infectious Diseases Unit, SS Trinità Hospital, Cagliari, Italy",
        "Unit of Infectious Diseases, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy"
      ],
      "name": "for the CISAI study group"
    }
  ],
  "title": "SC19 Weight and lipid changes after switching to long-acting cabotegravir and rilpivirine",
  "uid": "f0fca71a-b8cf-505e-9c17-4681a9dd1a2c"
}