{
  "abstract": "Objectives Describe the clinical evolution of a person with recurrent gonococcal cervicitis despite appropriate treatment and lack of reinfection.Methods We used the tolerance detection test to confirm that all three culture-positive gonococcal isolates were tolerant to ceftriaxone.Results Over a period of 6 months, a transgender man with gonococcal cervicitis experienced eight episodes of treatment failure despite receiving ceftriaxone 1 g intramuscularly on each occasion. The isolate remained susceptible to ceftriaxone throughout this period. His Neisseria gonorrhoeae infection was then successfully eradicated with a prolonged course of ceftriaxone.Conclusions We propose that bacterial tolerance be considered a possible cause of treatment failure in N. gonorrhoeae. A tolerance detection test can be used to diagnose tolerance.",
  "authors": [
    {
      "affiliations": [
        "Department of Infection Control and Prevention, Faculty of Nursing, Toho University Faculty of Medicine Graduate School of Medicine, Ota, Tokyo, Japan",
        "Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"
      ],
      "name": "Izumo Kanesaka"
    },
    {
      "affiliations": [
        "Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"
      ],
      "name": "Thibaut Vanbaelen"
    },
    {
      "affiliations": [
        "Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"
      ],
      "name": "Irith De Baetselier"
    },
    {
      "affiliations": [
        "Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"
      ],
      "name": "Dorien Van den Bossche"
    },
    {
      "affiliations": [
        "Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"
      ],
      "name": "Said Abdellati"
    },
    {
      "affiliations": [
        "Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"
      ],
      "name": "Tessa de Block"
    },
    {
      "affiliations": [
        "Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"
      ],
      "name": "Sheeba Santhini Manoharan-Basil"
    },
    {
      "affiliations": [
        "Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium",
        "Medicine, University of Cape Town, Rondebosch, South Africa"
      ],
      "name": "Chris Kenyon"
    }
  ],
  "title": "Could tolerance explain an individual’s eight episodes of gonococcal treatment failure with ceftriaxone? A case report",
  "uid": "c8897f92-d732-592b-82a9-5408772bd3b3"
}