{
  "abstract": "Objectives Long-acting injectable cabotegravir (LACAB) has proven to be superior to oral pre-exposure prophylaxis (PrEP); however, it represents an issue for PrEP management, given the relevant burden on clinic workload. This study aimed to describe (1) the proportion of users requiring LACAB for medical issues, (2) the proportion of users who wish to switch to LACAB and (3) the factors associated with prioritising LACAB based on a combination of medical and psychological needs.Methods Toxicity, adherence and efficacy issues were evaluated in PrEP users attending a community-based service. The same population underwent an online survey to measure their desire for and reasons for switching to LACAB. An adjusted model was developed to identify variables associated with both medical needs and interest in LACAB.Results A total of 1056 individuals were assessed for LACAB medical needs, and 27.8% were eligible, primarily due to adherence issues. Of the 419 survey respondents, 74.9% expressed interest in LACAB. Age older than 25 years, use of any other concomitant medication and reporting sexual encounters without PrEP or condom use were associated with both the medical need for LACAB and interest in this new preventive strategy.Conclusions The need for and desire to use LACAB are significant. The health system needs to be implemented to address the issues posed by this novel approach.",
  "authors": [
    {
      "affiliations": [
        "ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy",
        "Milano Checkpoint ETS, Milan, Italy"
      ],
      "name": "Roberto Rossotti"
    },
    {
      "affiliations": [
        "Milano Checkpoint ETS, Milan, Italy"
      ],
      "name": "Alessandra Bianchi"
    },
    {
      "affiliations": [
        "Fondazione ICONA, Milan, Italy",
        "Department of Public Health, Experimental and Forensic Medicine, National PhD Programme in One Health Approaches to Infectious Diseases and Life Science Research, University of Pavia, Pavia, Italy"
      ],
      "name": "Alessandro Tavelli"
    },
    {
      "affiliations": [
        "Milano Checkpoint ETS, Milan, Italy"
      ],
      "name": "Enrico Caruso"
    },
    {
      "affiliations": [
        "Milano Checkpoint ETS, Milan, Italy"
      ],
      "name": "Pietro Vinti"
    },
    {
      "affiliations": [
        "Milano Checkpoint ETS, Milan, Italy",
        "Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy"
      ],
      "name": "Alessandro G Soria"
    },
    {
      "affiliations": [
        "Milano Checkpoint ETS, Milan, Italy",
        "ASST Santi Paolo e Carlo, Milan, Italy"
      ],
      "name": "Anna De Bona"
    },
    {
      "affiliations": [
        "Milano Checkpoint ETS, Milan, Italy",
        "San Raffaele del Monte Tabor Foundation, Milan, Italy"
      ],
      "name": "Camilla Muccini"
    },
    {
      "affiliations": [
        "Milano Checkpoint ETS, Milan, Italy",
        "ASST Fatebenefratelli Sacco, Milan, Italy"
      ],
      "name": "Davide Moschese"
    },
    {
      "affiliations": [
        "Policlinico Agostino Gemelli IRCCS Foundation, Università Cattolica del Sacro Cuore, Milan, Italy"
      ],
      "name": "Antonella Cingolani"
    },
    {
      "affiliations": [
        "Milano Checkpoint ETS, Milan, Italy"
      ],
      "name": "Massimo Cernuschi"
    },
    {
      "affiliations": [
        "Fondazione ICONA, Milan, Italy"
      ],
      "name": "Antonella d’Arminio Monforte"
    }
  ],
  "title": "Medical and psychological needs for injectable long-acting cabotegravir as pre-exposure prophylaxis",
  "uid": "588f6000-0fd3-5008-b417-87dd01adb9f5"
}