{
  "abstract": "Objectives Describe the clinical, phenotypic and genomic characteristics of ceftriaxone-resistant Neisseria gonorrhoeae from Scotland.Methods Cases were identified in routine care from 2018 to 2024. Minimum inhibitory concentrations were determined for seven antimicrobial agents. Whole genome sequencing was performed with Illumina and Oxford Nanopore Technology instruments. A phylogeny containing global ceftriaxone-resistant genomes was generated with Parsnp. A collection of ST8780 genomes was also analysed to give further context using reference-based mapping with Snippy.Results There were five cases of ceftriaxone-resistant N. gonorrhoeae detected. One case (multilocus sequencing typing (MLST) ST1903) clustered within the FC428 lineage in a returning traveller from an Asia-Pacific country. Two cases belonged to the recently described extensively drug-resistant MLST ST16406, a returning traveller from an Asia-Pacific country and a sexual contact within Scotland. The final two cases were a resident of an Asia-Pacific country and a sexual contact within Scotland, both belonged to MLST ST8780. These were distinct from other publicly available ST8780 genomes, suggesting a novel introduction of the mosaic penA-60.001 allele. All cases were initially treated with ceftriaxone-based regimes, four returned for test of cure and showed clearance of infection.Conclusions As ceftriaxone resistance is increasingly identified, multiple public health interventions are required to reduce the impact of resistance on gonorrhoea treatment globally.",
  "authors": [
    {
      "affiliations": [
        "NHS Lothian, Edinburgh, UK",
        "Edinburgh Medical School, University of Edinburgh, Edinburgh, UK"
      ],
      "name": "Martin P McHugh"
    },
    {
      "affiliations": [
        "NHS Forth Valley, Stirling, UK"
      ],
      "name": "Kirsty Aburajab"
    },
    {
      "affiliations": [
        "NHS Greater Glasgow and Clyde, Glasgow, UK"
      ],
      "name": "Alexandra Maxwell"
    },
    {
      "affiliations": [
        "NHS Lothian, Edinburgh, UK"
      ],
      "name": "John Anderson"
    },
    {
      "affiliations": [
        "NHS Lothian, Edinburgh, UK"
      ],
      "name": "Fraser Cairns"
    },
    {
      "affiliations": [
        "NHS Lothian, Edinburgh, UK",
        "Edinburgh Medical School, University of Edinburgh, Edinburgh, UK"
      ],
      "name": "Seb Cotton"
    },
    {
      "affiliations": [
        "NHS Lothian, Edinburgh, UK"
      ],
      "name": "Andrew Gough"
    },
    {
      "affiliations": [
        "NHS Lothian, Edinburgh, UK"
      ],
      "name": "Brian Malloy"
    },
    {
      "affiliations": [
        "NHS Lothian, Edinburgh, UK"
      ],
      "name": "Katharine Mathers"
    },
    {
      "affiliations": [
        "NHS Lothian, Edinburgh, UK"
      ],
      "name": "Lynne Renwick"
    },
    {
      "affiliations": [
        "NHS Lothian, Edinburgh, UK"
      ],
      "name": "Jill Shepherd"
    },
    {
      "affiliations": [
        "NHS Lothian, Edinburgh, UK",
        "Edinburgh Medical School, University of Edinburgh, Edinburgh, UK"
      ],
      "name": "Kate E Templeton"
    }
  ],
  "title": "Investigation of ceftriaxone-resistant Neisseria gonorrhoeae detected in Scotland, 2018–2024",
  "uid": "fcaf3274-57ab-5970-8cd6-82efed3d193c"
}