{
  "abstract": "Introduction Despite high HIV prevalence rates among trans women (TW), few preventive interventions have targeted this population.Methods We described sociodemographic and clinical data from a cohort of TW followed up for pre-exposure prophylaxis (PrEP) at the Sexual Health Clinic of Bichat hospital in Paris between 2016 and 2023, via a multidisciplinary community-led PrEP programme.The total number of TW starting PrEP and having ongoing follow-up each year was assessed. We described retention in care at 3, 6 and 12 months and median time of follow-up. Incidence of PrEP discontinuation was calculated using Poisson regression.Results Between January 2016 and December 2023, 209 TW have been followed up for PrEP at Bichat Hospital, with a median age of 36 years and mostly originating from South America (79.4%, 166/209). Seventy-four per cent of TW (155/209) were sex workers and 53.6% (112/209) had regular health insurance. Most of TW were on daily PrEP (94.3 %, 197/209).The total number of TW followed-up for PrEP per year increased from 17 in 2016 to 129 in 2023. Median time of follow-up was 10.3 months and incidence of PrEP discontinuations was 58.2 (CI 95% 49.51 to 68.57) per 100 persons-year. Retention in care at 6 and 12 months was, respectively, 62% and 38% for users who started PrEP in 2016 and 81% and 31% for those who started in 2022. Seven per cent of TW (13/190) experienced adverse events, leading to PrEP discontinuation in 10/190 cases. Two cases of HIV seroconversion were reported, both in TW who had stopped PrEP for gastrointestinal intolerance.Conclusions Our multidisciplinary reach-out community-led PrEP programme has increased PrEP access among our cohort of TW. Rates of retention in such a prevention programme of care remained poor. More interventions are needed to analyse PrEP barriers and improve retention in care for this specific population.",
  "authors": [
    {
      "affiliations": [
        "Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, Hôpital Bichat Claude-Bernard, Paris, Île-de-France, France"
      ],
      "name": "Valentina Isernia"
    },
    {
      "affiliations": [
        "Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, Hôpital Bichat Claude-Bernard, Paris, Île-de-France, France"
      ],
      "name": "Minerva Cervantes"
    },
    {
      "affiliations": [
        "Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, Hôpital Bichat Claude-Bernard, Paris, Île-de-France, France",
        "COREVIH IDF Nord, Paris, France"
      ],
      "name": "Marc Digumber"
    },
    {
      "affiliations": [
        "Acceptess-T, Paris, France"
      ],
      "name": "Frezzia Peralta"
    },
    {
      "affiliations": [
        "COREVIH IDF Nord, Paris, France"
      ],
      "name": "Françoise Louni"
    },
    {
      "affiliations": [
        "Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, Hôpital Bichat Claude-Bernard, Paris, Île-de-France, France"
      ],
      "name": "André Deprez"
    },
    {
      "affiliations": [
        "Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, Hôpital Bichat Claude-Bernard, Paris, Île-de-France, France",
        "COREVIH IDF Nord, Paris, France"
      ],
      "name": "Sylvie Le Gac"
    },
    {
      "affiliations": [
        "Acceptess-T, Paris, France"
      ],
      "name": "Claire Vandendriessche"
    },
    {
      "affiliations": [
        "INSERM, Paris, France"
      ],
      "name": "Karen Champenois"
    },
    {
      "affiliations": [
        "Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, Hôpital Bichat Claude-Bernard, Paris, Île-de-France, France"
      ],
      "name": "Aurelie Sautereau"
    },
    {
      "affiliations": [
        "Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, Hôpital Bichat Claude-Bernard, Paris, Île-de-France, France"
      ],
      "name": "Antoine Bachelard"
    },
    {
      "affiliations": [
        "Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, Hôpital Bichat Claude-Bernard, Paris, Île-de-France, France"
      ],
      "name": "Bao Phung"
    },
    {
      "affiliations": [
        "IMEA, Paris, Île-de-France, France"
      ],
      "name": "Aïda Benalycherif"
    },
    {
      "affiliations": [
        "Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, Hôpital Bichat Claude-Bernard, Paris, Île-de-France, France",
        "IMEA, Paris, Île-de-France, France"
      ],
      "name": "Roland Landman"
    },
    {
      "affiliations": [
        "Acceptess-T, Paris, France"
      ],
      "name": "Laszlo Blanquart"
    },
    {
      "affiliations": [
        "Infectious diseases, Hopital Bichat-Claude-Bernard, Paris, France, Hôpital Bichat Claude-Bernard, Paris, Île-de-France, France",
        "INSERM, Paris, France"
      ],
      "name": "Jade Ghosn"
    }
  ],
  "title": "Pre-exposure prophylaxis (PrEP) uptake and retention in care in a group of transgender women at high risk of HIV: a French cohort of follow-up",
  "uid": "91c1e5be-6781-5fbb-af4a-039cca6bf64f"
}