{
  "abstract": "Takayasu arteritis (TAK) remains a therapeutic challenge, and some patients develop refractory disease despite conventional immunosuppression and established biologics.1 2 We report here the data from the BIOTAK registry of multicentre experience with Janus kinase (JAK) inhibitors in 20 patients with refractory TAK, demonstrating promising efficacy and acceptable safety profiles.",
  "authors": [
    {
      "affiliations": [
        "Sorbonne Université, AP-HP, Hôpital Saint Antoine, service de médecine interne et Inflammation-Immunopathology-Biotherapy Department (DMU i3), France and French Armenian research center, Paris, France"
      ],
      "name": "Arsène Mekinian"
    },
    {
      "affiliations": [
        "Université de Paris, AP-HP, Hôpital Saint Louis, Service de Biostatistique et Information Médicale (DMU PRISME), INSERM U1153 Team ECSTRRA, Paris, France"
      ],
      "name": "Sarah Meneses"
    },
    {
      "affiliations": [
        "Université de Paris, AP-HP, Hôpital Saint Louis, Service de Biostatistique et Information Médicale (DMU PRISME), INSERM U1153 Team ECSTRRA, Paris, France"
      ],
      "name": "Lucie Biard"
    },
    {
      "affiliations": [
        "Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy"
      ],
      "name": "Lorenzo Dagna"
    },
    {
      "affiliations": [
        "Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russia"
      ],
      "name": "Pavel Novikov"
    },
    {
      "affiliations": [
        "Division of Rheumatology, Azienda USL-IRCCS of Reggio Emilia, University of Modena and Reggio Emilia, Reggio Emilia, Italy"
      ],
      "name": "Carlo Salvarani"
    },
    {
      "affiliations": [
        "CHU Nantes, Department of internal and vascular medicine, Nantes Universite, Nantes, France"
      ],
      "name": "Olivier Espitia"
    },
    {
      "affiliations": [
        "Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain"
      ],
      "name": "José Hernández-Rodríguez"
    },
    {
      "affiliations": [
        "Département de Médecine Interne, Hôpital Bichat, Université de Paris, Assistance Publique Hôpitaux de Paris, INSERM U1149, Paris, France"
      ],
      "name": "Karim Sacre"
    },
    {
      "affiliations": [
        "Service de médecine interne, CHU de Blois, Blois, France"
      ],
      "name": "Bertrand Lioger"
    },
    {
      "affiliations": [
        "University of Lorraine, Inserm UMR_S 1116, CHRU de Nancy, Vascular Medicine Division and national reference Center for Rare Vascular and Systemic Autoimmune Diseases, Nancy, France"
      ],
      "name": "Virginie Dufrost"
    },
    {
      "affiliations": [
        "Department of Internal Medicine and Clinical Immunology, CHRU Tours, University of Tours, Tours, France"
      ],
      "name": "Alexandra Audemard-Verger"
    },
    {
      "affiliations": [
        "Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy",
        "Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan",
        "Department of Internal Medicine and Rheumatology, Nairi Hospital, Erevan, Armenia"
      ],
      "name": "Alessandro Tomelleri"
    },
    {
      "affiliations": [
        "Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan",
        "Service de rhumatologie, Hôpital Montfermeil, GHI Le Raincy Montfermeil, Montfermeil, France"
      ],
      "name": "Masataka Kuwana"
    },
    {
      "affiliations": [
        "Department of Internal Medicine and Rheumatology, Nairi Hospital, Erevan, Armenia",
        "Department of Internal Medicine and Clinical Immunology France, Centre national de référence maladies Autoimmunes Systémiques rares, Centre national de référence maladies Autoinflammatoires et Amylose, and Inflammation-Immunopathology-Biotherapy Department (DMU i3), Sorbonne Université, AP-HP, Hôpital Pitié Salpetrière, Paris, France"
      ],
      "name": "Vahan Mukuchyan"
    },
    {
      "affiliations": [
        "Service de rhumatologie, Hôpital Montfermeil, GHI Le Raincy Montfermeil, Montfermeil, France"
      ],
      "name": "Azeddine Dellal"
    },
    {
      "affiliations": [
        "Division of Rheumatology, Azienda USL-IRCCS of Reggio Emilia, University of Modena and Reggio Emilia, Reggio Emilia, Italy"
      ],
      "name": "Francesco Muratore"
    },
    {
      "affiliations": [
        "Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy"
      ],
      "name": "Corrado Campochiaro"
    },
    {
      "affiliations": [
        "Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russia"
      ],
      "name": "Sergey Moiseev"
    },
    {
      "affiliations": [
        "Department of Internal Medicine and Clinical Immunology France, Centre national de référence maladies Autoimmunes Systémiques rares, Centre national de référence maladies Autoinflammatoires et Amylose, and Inflammation-Immunopathology-Biotherapy Department (DMU i3), Sorbonne Université, AP-HP, Hôpital Pitié Salpetrière, Paris, France"
      ],
      "name": "Patrice Cacoub"
    },
    {
      "affiliations": [
        "Sorbonne Université, AP-HP, Hôpital Saint Antoine, service de médecine interne et Inflammation-Immunopathology-Biotherapy Department (DMU i3), France and French Armenian research center, Paris, France"
      ],
      "name": "Olivier Fain"
    },
    {
      "affiliations": [
        "Department of Internal Medicine and Clinical Immunology France, Centre national de référence maladies Autoimmunes Systémiques rares, Centre national de référence maladies Autoinflammatoires et Amylose, and Inflammation-Immunopathology-Biotherapy Department (DMU i3), Sorbonne Université, AP-HP, Hôpital Pitié Salpetrière, Paris, France"
      ],
      "name": "David Saadoun"
    },
    {
      "affiliations": [],
      "name": "for the French Takayasu network"
    }
  ],
  "title": "Salvage therapy with JAK inhibitors in refractory Takayasu arteritis: a multicentre experience",
  "uid": "d7452489-54ce-5792-826e-de4793acc540"
}