{
  "abstract": "Objective The aim of this study was to investigate the relationship between antineutrophil cytoplasmic antibodies (ANCA) specificity and the risk of major adverse cardiovascular events (MACE) in patients with ANCA-associated vasculitis (AAV).Methods We conducted a retrospective study using the ANCA-associated vasculitis Toulouse cohort. The incidence of MACE, defined as myocardial infarction (MI) and/or stroke and/or all-cause death, was compared among patients according to their ANCA specificity. We also applied Cox regression models adjusted for traditional cardiovascular risk factors, age and sex to assess the risk of MI, stroke and MACE.Results A total of 402 patients were included, of whom 166 (41%) had antiproteinase 3 (anti-PR3) ANCA and 236 (59%) had antimyeloperoxidase (anti-MPO) ANCA. We identified 78 MACE during the follow-up period, including 15 MIs, 12 strokes and 62 deaths. The incidence rate of MACE in the ANCA+anti-PR3+ group was 21.4 per 1000 patient-years compared with 33.1 per 1000 patient-years in the ANCA+anti-MPO+ group (p=0.036). The time elapsed between the diagnosis of AAV and MACE occurrence was significantly shorter in the ANCA+anti-MPO+ group. The Cox regression model found that patients with anti-MPO ANCA tend to present more MACE, but the association was not statistically significant (HR 1.62; 95% CI 0.98 to 2.66; p=0.06). An association was found between the presence of anti-PR3 ANCA and a lower risk of strokes (HR 0.61; 95% CI 0.37 to 0.99; p=0.049) and none with the risk of MI.Conclusion Patients with anti-MPO ANCA appear to be at a higher risk of a composite MACE-all-cause mortality outcome than patients with anti-PR3 ANCA.",
  "authors": [
    {
      "affiliations": [
        "Internal Medicine, Hôpital Tenon, Paris, France"
      ],
      "name": "Jon Idoate Lacasia"
    },
    {
      "affiliations": [
        "Internal Medicine, CHU Toulouse, Toulouse, France"
      ],
      "name": "Morgane Mourguet"
    },
    {
      "affiliations": [
        "Pneumology, CHU Toulouse, Toulouse, France"
      ],
      "name": "Thomas Villeneuve"
    },
    {
      "affiliations": [
        "Nephrology and Organ Transplantation, CHU Toulouse, Toulouse, France"
      ],
      "name": "Alexis Cassard"
    },
    {
      "affiliations": [
        "Internal Medicine, CHU Toulouse, Toulouse, France"
      ],
      "name": "Laurent Alric"
    },
    {
      "affiliations": [
        "Internal Medicine, CHU Toulouse, Toulouse, France"
      ],
      "name": "Sebastien De Almeida Chaves"
    },
    {
      "affiliations": [
        "Internal Medicine, CHU Toulouse, Toulouse, France"
      ],
      "name": "Guillaume Moulis"
    },
    {
      "affiliations": [
        "Internal Medicine, CHU Toulouse, Toulouse, France"
      ],
      "name": "Marie Piel-Julian"
    },
    {
      "affiliations": [
        "Internal Medicine, CHU Toulouse, Toulouse, France"
      ],
      "name": "Laurent Sailler"
    },
    {
      "affiliations": [
        "Nephrology and Organ Transplantation, CHU Toulouse, Toulouse, France"
      ],
      "name": "Dominique Chauveau"
    },
    {
      "affiliations": [
        "Nephrology and Organ Transplantation Department, CHU Toulouse, Toulouse, France"
      ],
      "name": "Stanislas Faguer"
    },
    {
      "affiliations": [
        "Nephrology and Organ Transplantation, CHU Toulouse, Toulouse, France"
      ],
      "name": "Antoine Huart"
    },
    {
      "affiliations": [
        "Nephrology and Organ Transplantation, CHU Toulouse, Toulouse, France"
      ],
      "name": "David Ribes"
    },
    {
      "affiliations": [
        "Pneumology, CHU Toulouse, Toulouse, France"
      ],
      "name": "Laurent Guilleminault"
    },
    {
      "affiliations": [
        "Pneumology, CHU Toulouse, Toulouse, France"
      ],
      "name": "Grégoire Prévot"
    },
    {
      "affiliations": [
        "Immunologie biologique, CHU Toulouse, Toulouse, France"
      ],
      "name": "Chloe Bost"
    },
    {
      "affiliations": [
        "Rheumatology, CHU Toulouse, Toulouse, France"
      ],
      "name": "Arnaud Constantin"
    },
    {
      "affiliations": [
        "Rheumatology, CHU Toulouse, Toulouse, France"
      ],
      "name": "Guillaume Couture"
    },
    {
      "affiliations": [
        "Internal Medicine, Auch Hospital Center, Auch, France"
      ],
      "name": "Francis Gaches"
    },
    {
      "affiliations": [
        "Internal Medicine, Saint Exupéry Clinic, Toulouse, France"
      ],
      "name": "Martin Michaud"
    },
    {
      "affiliations": [
        "Ear-Nose-Throat, CHU Toulouse, Toulouse, France"
      ],
      "name": "Emmanuelle Mouchon"
    },
    {
      "affiliations": [
        "Cardiology, CHU Toulouse, Toulouse, France"
      ],
      "name": "Olivier Lairez"
    },
    {
      "affiliations": [
        "Internal Medicine, CHU Toulouse, Toulouse, France"
      ],
      "name": "Grégory Pugnet"
    }
  ],
  "title": "Impact of ANCA specificity on risk of cardiovascular events and death in ANCA-associated vasculitis",
  "uid": "343904c5-e73c-5b73-b055-0611dc022041"
}