{
  "abstract": "Objectives To assess the incidence and risk factors for arrhythmias in patients with psoriatic arthritis (PsA).Methods We performed a cohort analysis of patients followed prospectively from 1994 to 2024. Participants were evaluated using standard protocols at 6-to-12-month intervals. The following events were assessed: (1) atrial tachyarrhythmia (including atrial fibrillation and supraventricular tachycardia); (2) ventricular tachyarrhythmia and (3) bradycardia/pacemaker. The cumulative incidence rate (CIR) of each arrhythmia was calculated. Cox proportional hazards models (reported as the current level HR (measured just prior to the event) and the adjusted mean HR) were fitted to assess the association between selected measures of PsA disease activity and the age of occurrence of arrhythmia events. Each model was adjusted for sex, PsA duration, cardiovascular risk factors and medications.Results A total of 1670 patients with PsA were analysed (80 atrial tachyarrhythmias, 17 bradyarrhythmias/pacemakers and 11 ventricular tachyarrhythmias). By age 70, the CIRs were 7.82%, 0.67% and 0.45% for atrial, ventricular and bradycardia, respectively. In multivariable analysis, remission/low versus high disease activity state was associated with lower risk of atrial tachyarrhythmia (current HR 0.49, 95% CI 0.26 to 0.92; adjusted mean HR 0.46, 95% CI 0.23 to 0.91). Similarly, a higher three-item Visual Analogue Scale (3-VAS) was associated with a higher risk of atrial tachyarrhythmia (current level HR 1.18, 95% CI 1.04 to 1.33; adjusted mean HR 1.22, 95% CI 1.04 to 1.44).Conclusions Higher PsA disease activity is associated with higher atrial tachyarrhythmia risk. These findings reinforce the importance of controlling inflammation in PsA to optimise cardiac health.",
  "authors": [
    {
      "affiliations": [
        "Department of Medicine, University of Toronto, Toronto, Ontario, Canada",
        "Department of Medicine, Women’s College Hospital, Toronto, Ontario, Canada",
        "Department of Medicine, King Faisal Specialist Hospital and Research Centre, Madinah, Saudi Arabia"
      ],
      "name": "Abdulrahman Y Almansouri"
    },
    {
      "affiliations": [
        "Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada"
      ],
      "name": "Jiayi Li"
    },
    {
      "affiliations": [
        "Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada"
      ],
      "name": "Laura Bumbulis"
    },
    {
      "affiliations": [
        "Department of Medicine, University of Toronto, Toronto, Ontario, Canada",
        "Gladman Krembil Psoriatic Arthritis Program, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada",
        "Department of Medicine, King Fahad Hospital, Khamis Mushaiyt, Saudi Arabia"
      ],
      "name": "Ali Alhadari"
    },
    {
      "affiliations": [
        "Department of Medicine, University of Toronto, Toronto, Ontario, Canada",
        "Department of Health and Society, University of Toronto, Toronto, Ontario, Canada"
      ],
      "name": "Keith Colaco"
    },
    {
      "affiliations": [
        "Department of Medicine, University of Toronto, Toronto, Ontario, Canada",
        "Department of Medicine, Women’s College Hospital, Toronto, Ontario, Canada"
      ],
      "name": "Paula Harvey"
    },
    {
      "affiliations": [
        "Department of Medicine, University of Toronto, Toronto, Ontario, Canada",
        "Department of Medicine, Women’s College Hospital, Toronto, Ontario, Canada"
      ],
      "name": "Shadi Akhtari"
    },
    {
      "affiliations": [
        "Department of Medicine, University of Toronto, Toronto, Ontario, Canada",
        "Gladman Krembil Psoriatic Arthritis Program, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada",
        "Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada",
        "Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada"
      ],
      "name": "Vinod Chandran"
    },
    {
      "affiliations": [
        "Department of Medicine, University of Toronto, Toronto, Ontario, Canada",
        "Gladman Krembil Psoriatic Arthritis Program, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada",
        "Department of Health and Society, University of Toronto, Toronto, Ontario, Canada",
        "Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada"
      ],
      "name": "Dafna D Gladman"
    },
    {
      "affiliations": [
        "Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada"
      ],
      "name": "Richard J Cook"
    },
    {
      "affiliations": [
        "Department of Medicine, University of Toronto, Toronto, Ontario, Canada",
        "Department of Medicine, Women’s College Hospital, Toronto, Ontario, Canada",
        "Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada"
      ],
      "name": "Lihi Eder"
    }
  ],
  "title": "Incidence rate and risk factors of arrhythmias in patients with psoriatic arthritis",
  "uid": "1fa45ecc-e6b9-5275-a649-05ca491dd085"
}