{
  "abstract": "Objectives The European Alliance of Associations for Rheumatology (EULAR) recommendations for the management of systemic lupus erythematosus (SLE) and lupus nephritis provide important guidance for practitioners on diagnosis, monitoring and treatment. However, practical barriers, such as time constraints, may pose challenges to practitioners when implementing these recommendations in real-world settings. We provide practical, expert-driven advice on how practitioners may effectively and efficiently implement the EULAR recommendations in routine clinical practice.Methods Eight international SLE experts convened and contributed opinions and advice for practitioners via an online survey containing 17 open-ended questions on implementation of the EULAR recommendations for early diagnosis, treatment targets and the use of glucocorticoids (GCs), immunosuppressants and biologics. Survey results were compiled and analysed to reach consensus on key advice points for each topic.Results Expert advice covered four key topics—setting standardised targets to help modify disease course and prevent organ damage; taking action to achieve these targets; monitoring of target achievement through validated clinical tools and frameworks; and optimising the therapeutic strategy to prevent flares and GC-associated toxicities. A total of 13 core expert-driven advice points were developed across these topics, including scenarios for consideration of earlier biological and/or conventional immunosuppressive use, specific risk factors for poorer prognosis to inform treatment decisions and suggestions on GC tapering.Conclusions These expert insights could facilitate implementation of the EULAR recommendations for the management of SLE in clinical practice, thereby helping patients achieve treatment targets and prevent and/or delay organ damage progression.",
  "authors": [
    {
      "affiliations": [
        "Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, and Center for Molecular Medicine (CMM), Stockholm, Sweden",
        "Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden"
      ],
      "name": "Ioannis Parodis"
    },
    {
      "affiliations": [
        "Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, Attikon University Hospital, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens School of Medicine, Athens, Greece"
      ],
      "name": "Antonis Fanouriakis"
    },
    {
      "affiliations": [
        "Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria S.Anna, Ferrara, Italy"
      ],
      "name": "Alessandra Bortoluzzi"
    },
    {
      "affiliations": [
        "Department of Rheumatology, Stadtspital Zürich, Zürich, Switzerland"
      ],
      "name": "Christof Iking-Konert"
    },
    {
      "affiliations": [
        "University Medical Center, Department of Nephrology, Rheumatology and Center of Immunotherapy, Mainz, Germany"
      ],
      "name": "Julia Weinmann-Menke"
    },
    {
      "affiliations": [
        "Respiratory, Immunology and Inflammation Unit, Europe Medical Affairs, GSK, Madrid, Spain"
      ],
      "name": "Carmen San Román"
    },
    {
      "affiliations": [
        "Respiratory, Immunology and Inflammation Unit, Global Medical Affairs, GSK, Collegeville, Pennsylvania, USA"
      ],
      "name": "Roger Abramino Levy"
    },
    {
      "affiliations": [
        "Division of Rheumatology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain"
      ],
      "name": "Inigo Rua-Figueroa"
    },
    {
      "affiliations": [
        "Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany",
        "German Rheumatism Research Centre (DRFZ) Berlin, a Leibniz Institute, Berlin, Germany"
      ],
      "name": "Tobias Alexander"
    },
    {
      "affiliations": [
        "Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses-Paris (CIMI PARIS), INSERM U1135, Paris, France",
        "Sorbonne Université, AP-HP, Groupement Hospitalier Pitié–Salpêtrière, Centre national de référence du lupus systémique, du syndrome des antiphospholipides et autres maladies auto-immunes, Service de Médecine Interne 2, Institut E3M, Paris, France"
      ],
      "name": "Zahir Amoura"
    }
  ],
  "title": "Practical insights for the clinical implementation of the EULAR recommendations for patients with systemic lupus erythematosus",
  "uid": "bbafbe54-d89e-55aa-a748-2aedd1cf264c"
}