{
  "abstract": "The management of rheumatoid arthritis (RA) has significantly improved, but a substantial number of patients still experience persistent disease activity, leading to the concept of ‘difficult-to-treat RA’ (D2T RA). The European Alliance of Associations for Rheumatology (EULAR) has provided a pivotal definition for D2T RA to unify clinical approaches and research methods. This definition frames D2T RA as an umbrella term for a diverse group of patients with management challenges stemming from various factors, including biological resistance, patient experience, and clinical complexities. This framework is invaluable for a previously ill-defined population, but its real-life application highlights areas for ongoing consideration and potential refinement. Here, we discuss some of the strengths and limitations of the EULAR definition for D2T RA.",
  "authors": [
    {
      "affiliations": [
        "Department of Rheumatology and Immunology, Semmelweis University, Budapest, Hungary",
        "Heart and Vascular Center, Semmelweis University, Budapest, Hungary",
        "Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary"
      ],
      "name": "György Nagy"
    },
    {
      "affiliations": [
        "Centre for Musculoskeletal Research, Division of Musculoskeletal & Dermatological Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK",
        "NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"
      ],
      "name": "Maya H Buch"
    }
  ],
  "title": "Strengths and limitations of the EULAR definition for difficult-to-treat rheumatoid arthritis",
  "uid": "3fb2dd98-6af9-5910-86ac-2e834a35923a"
}