{
  "abstract": "Objectives To investigate the relationship between body weight fluctuation and the progression of knee pain and joint space loss (JSL) in people with radiographic knee osteoarthritis (RKOA) during a 48-month follow-up period.Design We conducted a longitudinal study using data from the Osteoarthritis Initiative. We analysed body weight variability through metrics of average successive variability (ASV), and residual ASV from baseline to 48 months. We assessed the impact of the fluctuations on changes in the Western Ontario and McMaster Universities Osteoarthritis Index pain scores and JSL, defined as a decrease of ≥0.7 mm in medial joint space width (JSW), using generalised estimating equations to account for correlation within-person and adjusted for covariates.Results A total of 2993 and 2789 knees from 2051 participants were included in the pain and JSW analyses, respectively. Higher body weight variability correlated with increased knee pain but not JSL. Participants with high variability (ASV ≥2.07 kg) had a greater OR of aggravated knee pain (OR: 1.24, 95% CI: 1.01 to 1.51, MD: 0.30, 95% CI: 0.05 to 0.54), particularly among initially overweight or obese individuals (OR: 1.30, 95% CI: 1.05 to 1.62, MD: 0.35, 95% CI: 0.08 to 0.62) and those who gained over 3% body weight (OR: 1.54, 95% CI: 1.01 to 2.33, MD: 0.65, 95% CI: 0.16 to 1.14).Conclusions Body weight fluctuations are a potential risk factor for symptom progression in RKOA, especially among overweight/obese individuals or those who gain weight. Maintaining a stable body weight may help alleviate the progression of symptoms related to knee osteoarthritis.",
  "authors": [
    {
      "affiliations": [
        "Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"
      ],
      "name": "Kai Fu"
    },
    {
      "affiliations": [
        "Department of Physical Medicine and Rehabilitation, Mandalay General Hospital, University of Medicine Mandalay, Mandalay, Myanmar"
      ],
      "name": "Win Min Oo"
    },
    {
      "affiliations": [
        "Osteoarthritis Research Unit, University of Montreal Hospital Centre Research Centre (CRCHUM), Montreal, Quebec, Canada"
      ],
      "name": "Jean-Pierre Pelletier"
    },
    {
      "affiliations": [
        "Osteoarthritis Research Unit, University of Montreal Hospital Centre Research Centre (CRCHUM), Montreal, Quebec, Canada"
      ],
      "name": "Johanne Martel-Pelletier"
    },
    {
      "affiliations": [
        "Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"
      ],
      "name": "Yong Feng"
    },
    {
      "affiliations": [
        "Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"
      ],
      "name": "Changqing Zhang"
    },
    {
      "affiliations": [
        "Shanghai Institute of Microsurgery on Extremities, and Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"
      ],
      "name": "Qianying Cai"
    },
    {
      "affiliations": [
        "Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China",
        "Clinical Research Centre, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China",
        "Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia"
      ],
      "name": "Changhai Ding"
    },
    {
      "affiliations": [
        "School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia"
      ],
      "name": "Flavia Cicuttini"
    },
    {
      "affiliations": [
        "Kolling Institute, Sydney Musculoskeletal Health, The University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "David J. Hunter"
    }
  ],
  "title": "Association between body weight fluctuation and progression of radiographic knee osteoarthritis: a longitudinal cohort study",
  "uid": "50e33650-a72a-56fa-9f1d-177da72b5ed5"
}