{
  "abstract": "Objective This population-based study aimed to determine timing and incidence of arterial and venous thromboembolic events (TE) and antiphospholipid syndrome (APS) relative to systemic lupus erythematosus (SLE) onset and assess relationships between TE, APS and anti-phospholipid antibodies (aPL) during follow-up.Methods We included all medical-record confirmed new-onset SLE patients in Southeast Norway (population 2.9 million) 2000–2017 who fulfilled the 2019 European Alliance of Rheumatology Associations/American College of Rheumatology classification criteria. APS was defined by the 2006 Sydney classification criteria, and aPL positivity was determined following international guidelines. Key outcomes were APS, TE and death. We estimated outcome-free survival using Kaplan-Meier methods.Results Among 700 new-onset SLE patients followed for a mean of 8 years (SD 5.0), 13% (89/700) experienced a new TE. TE incidence peaked at 59 per 100 person-years (95% CI 38 to 87) in the first year of SLE among aPL positive patients diagnosed with APS, falling to 12 (95% CI 6.2 to 21) in the subsequent 4 years. In patients without APS, corresponding TE incidences were 2.6 (95% CI 1.4 to 4.3) and 0.9 (95% CI 0.5 to 1.4), respectively. The lowest TE incidence was in aPL-negative patients aged <50 years, with 1-year TE-free survival of 0.99 (95% CI 0.97 to 1.0). Beyond the first year, TE-free survival rates did not differ between SLE patients positive and negative for aPL. Standardised mortality rate in patients with and without APS was 4.7 (95% CI 1.8 to 10.7 and 1.7 (95% CI 1.2 to 2.3).Conclusions This population-level study reveals high risk of TE, particularly for aPL positive patients around the time of SLE diagnosis. The elevated TE risk requires attention and early preventive strategies in newly diagnosed SLE.",
  "authors": [
    {
      "affiliations": [
        "Department of Rheumatology, Oslo University Hospital, Oslo, Norway",
        "Institute of Clincal Medicine, Faculty of Medicine University of Oslo, Oslo, Norway"
      ],
      "name": "Sigrid Reppe Moe"
    },
    {
      "affiliations": [
        "Department of Rheumatology, Oslo University Hospital, Oslo, Norway",
        "Institute of Clincal Medicine, Faculty of Medicine University of Oslo, Oslo, Norway",
        "Department of Rheumatology, Martina Hansens Hospital, Gjettum, Norway"
      ],
      "name": "Hilde Haukeland"
    },
    {
      "affiliations": [
        "Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway"
      ],
      "name": "Cathrine Brunborg"
    },
    {
      "affiliations": [
        "Department of Rheumatology, Betanien Hospital, Skien, Norway"
      ],
      "name": "Antonela Botea"
    },
    {
      "affiliations": [
        "Department of Rheumatology, Østfold Hospital, Grålum, Norway"
      ],
      "name": "Nenad Damjanic"
    },
    {
      "affiliations": [
        "Division of Rheumatology, Department of Medicine, Sorlandet Hospital Kristiansand, Kristiansand, Norway"
      ],
      "name": "Gro Årthun Wivestad"
    },
    {
      "affiliations": [
        "Department of Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway"
      ],
      "name": "Heidi Kverneggen Øvreås"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Vestfold Hospital Trust, Tønsberg, Norway"
      ],
      "name": "Thea Bjerkestrand Bøe"
    },
    {
      "affiliations": [
        "Department of Rheumatology, Vestre Viken Hospital Trust, Drammen, Norway"
      ],
      "name": "Anniken Orre"
    },
    {
      "affiliations": [
        "Department of Rheumatology, Oslo University Hospital, Oslo, Norway"
      ],
      "name": "Garen Torhild"
    },
    {
      "affiliations": [
        "Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway",
        "Section for Public Health, Hamar, Norway, Innland Norway University of Applied Sciences, Hamar, Norway"
      ],
      "name": "Sella Aarrestad Provan"
    },
    {
      "affiliations": [
        "Department of Rheumatology, Oslo University Hospital, Oslo, Norway",
        "Institute of Clincal Medicine, Faculty of Medicine University of Oslo, Oslo, Norway"
      ],
      "name": "Øyvind Molberg"
    },
    {
      "affiliations": [
        "Department of Rheumatology, Oslo University Hospital, Oslo, Norway"
      ],
      "name": "Karoline Lerang"
    }
  ],
  "title": "Accrual of thromboembolic events and antiphospholipid syndrome in new-onset systemic lupus erythematosus: a population-based inception cohort study",
  "uid": "73f7f181-5d2a-54e0-bfbc-4487e6313a84"
}