{
  "abstract": "Objectives To estimate shared genetic susceptibility between major subtypes of idiopathic inflammatory myopathies (IIM) and B cell lymphomas.Methods We paired summary statistics from genome-wide association studies (GWASs) of diffuse large B cell lymphoma, follicular lymphoma (FL), chronic lymphocytic leukaemia (CLL) and marginal zone lymphoma with those of dermatomyositis (DM) and polymyositis (PM) from a GWAS and an ImmunoChip study. We estimated local genetic correlation (r g) for each disease pair using local analysis of (co)variant association (Bonferroni-corrected p value<0.05) and identified genetic variants jointly associated with both diseases using pleiotropy-informed false discovery rate (conjunctional false discovery rate <0.05). Functional mapping and annotation analyses were also performed.Results We identified significant r g (ranging from −0.50 to 0.84) across 16 loci, with half located in the human leucocyte antigen (HLA) region, for the disease pairs of IIM and B cell lymphoma subtypes. Furthermore, jointly associated single-nucleotide polymorphisms were predominantly found in the HLA region. Specifically, all disease pairs showed shared genetic susceptibility in the HLA class I regions, while additional correlations in class III and class II regions were specific to DM and PM disease pairs, respectively. For some non-HLA loci with significant rg, functional analyses revealed immune-related responses potentially overlapping between DM and FL, DM and CLL, and PM and CLL.Conclusion We revealed that DM and PM share genetic susceptibility with common B cell lymphoma subtypes in both immune-related loci and loci with unclear biological functions. These novel findings improve our understanding of the pathological link between IIM and B cell lymphomas.",
  "authors": [
    {
      "affiliations": [
        "Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Taipa, Macao"
      ],
      "name": "Weng Ian Che"
    },
    {
      "affiliations": [
        "Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden"
      ],
      "name": "Anton Öberg Sysojev"
    },
    {
      "affiliations": [
        "Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas, USA"
      ],
      "name": "Catherine Zhu"
    },
    {
      "affiliations": [
        "Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden"
      ],
      "name": "Karina Patasova"
    },
    {
      "affiliations": [
        "Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Taipa, Macao",
        "Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden",
        "Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas, USA",
        "Medical unit Hematology, Theme Cancer, Karolinska University Hospital, Stockholm, Sweden",
        "Rheumatology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden",
        "ME Gastro, Dermatology and Rheumatology, Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden"
      ],
      "name": "International Lymphoma Epidemiology Consortium (InterLymph)"
    },
    {
      "affiliations": [
        "Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Taipa, Macao",
        "Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden",
        "Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas, USA",
        "Medical unit Hematology, Theme Cancer, Karolinska University Hospital, Stockholm, Sweden",
        "Rheumatology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden",
        "ME Gastro, Dermatology and Rheumatology, Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden"
      ],
      "name": "IMACS Myositis Genetics Scientific Interest Group (MYOGEN)"
    },
    {
      "affiliations": [
        "Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden",
        "Medical unit Hematology, Theme Cancer, Karolinska University Hospital, Stockholm, Sweden"
      ],
      "name": "Karin E Smedby"
    },
    {
      "affiliations": [
        "Rheumatology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden",
        "ME Gastro, Dermatology and Rheumatology, Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden"
      ],
      "name": "Ingrid E Lundberg"
    },
    {
      "affiliations": [
        "Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden"
      ],
      "name": "Helga Westerlind"
    },
    {
      "affiliations": [
        "Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden",
        "ME Gastro, Dermatology and Rheumatology, Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden"
      ],
      "name": "Marie Holmqvist"
    }
  ],
  "title": "Shared genetic susceptibility between idiopathic inflammatory myopathies and common B cell lymphoma subtypes found primarily in the human leucocyte antigen region",
  "uid": "2dacab1f-36e2-5011-9762-a0f829f5a7eb"
}