{
  "abstract": "We read with interest the study by Istenič et al,1 which provides quantitative data on bupivacaine distribution using high-performance liquid chromatography coupled with mass spectometry (HPLC-MS) in cadaveric tissue. The authors should be commended for addressing an important limitation of experimental models of interfascial plane blocks. Their second hypothesis, that bupivacaine permeates fascial layers to a greater extent than hydrophilic visual tracers, is supported by the presented data.",
  "authors": [
    {
      "affiliations": [
        "Department of Anaesthesiology and Critical Care, CHU de Lille, Lille, France",
        "Univ Lille, ULR 7365 - GRITA : Groupe de Recherche sur les formes Injectables et les Technologies Associées, Lille, France, Universite de Lille, Lille, Hauts-de-France, France"
      ],
      "name": "Damien Rousseleau"
    },
    {
      "affiliations": [
        "Department of Anaesthesiology and Critical Care, CHU de Lille, Lille, France",
        "Univ Lille, ULR 2694 - METRICS : Évaluation des technologies de santé et des pratiques médicales, Lille, France, Universite de Lille, Lille, Hauts-de-France, France"
      ],
      "name": "Cédric Cirenei"
    },
    {
      "affiliations": [
        "Department of Anaesthesiology and Critical Care, CHU de Lille, Lille, France",
        "Department of Anatomy, Lille University School of Medicine, Lille, France, Université de Lille, Lille, Hauts-de-France, France"
      ],
      "name": "Matthias Herteleer"
    }
  ],
  "title": "Bupivacaine spread beyond fascial planes and its pharmacodynamic relevance",
  "uid": "ea8c5b82-0b22-5b35-9a95-c07840196465"
}