{
  "abstract": "Background/Importance Chronic pain affects many people globally, requiring alternative management strategies. Psilocybin is gaining attention for its potential in chronic pain management despite being classified as Schedule I.Objective This systematic review critically evaluates the evidence for psilocybin, a Schedule I substance, in the treatment of chronic pain. The exact purpose of the review is to assess the impact of psilocybin on chronic pain relief, focusing on dosing protocols, treated conditions, and patient outcomes.Evidence Review A comprehensive review of PubMed, CINAHL, Web of Science, Cochrane Library, and EMBASE was conducted up to January 2024. Eligibility criteria included studies evaluating psilocybin for chronic pain management. The risk of bias was assessed using the MASTER (MethodologicAl STandards for Epidemiological Research) scale, and the strength of evidence was graded using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation).Findings The review identified 28 relevant studies focusing on dosing, treated conditions, and outcomes. The majority of the included studies (76.2%) were of low or very low quality. Several studies with moderate-to-low-quality evidence utilized a 0.14 mg/kg dosing protocol. The findings suggest promise for the use of psilocybin in chronic pain relief, though the quality of evidence is generally low.Conclusions The current research shows potential for psilocybin as a treatment option for chronic pain relief. However, methodological issues and a lack of high-quality evidence underscore the need for further investigations with standardized protocols. Despite these limitations, the potential for psilocybin in chronic pain management is encouraging.PROSPERO registration number CRD42023493823.",
  "authors": [
    {
      "affiliations": [
        "Physical Medicine & Rehabilitation, New York University Grossman School of Medicine, New York, New York, USA"
      ],
      "name": "David S Jevotovsky"
    },
    {
      "affiliations": [
        "Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"
      ],
      "name": "Harman Chopra"
    },
    {
      "affiliations": [
        "Anesthesiology, Weill Cornell Medical College, New York, New York, USA"
      ],
      "name": "Daniel J Pak"
    },
    {
      "affiliations": [
        "Anesthesiology, Pain Medicine Division, Vanderbilt University School of Medicine, Nashville, Tennessee, USA"
      ],
      "name": "Shravani Durbhakula"
    },
    {
      "affiliations": [
        "Physical Medicine & Rehabilitation, Hackensack Meridian JFK Johnson Rehabilitation Institute, Edison, New Jersey, USA"
      ],
      "name": "Alexander Shustorovich"
    },
    {
      "affiliations": [
        "Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"
      ],
      "name": "Tanya Juneja"
    },
    {
      "affiliations": [
        "Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"
      ],
      "name": "Mustafa Y Broachwala"
    },
    {
      "affiliations": [
        "Interventional Spine & Pain, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Tariq AlFarra"
    },
    {
      "affiliations": [
        "Physical Medicine & Rehabilitation, New York University Grossman School of Medicine, New York, New York, USA"
      ],
      "name": "Caroline Silver"
    },
    {
      "affiliations": [
        "The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA"
      ],
      "name": "Greg Kreitzer"
    },
    {
      "affiliations": [
        "Psychiatry, Cooper University Health Care, Camden, New Jersey, USA"
      ],
      "name": "Philip Oreoluwa"
    },
    {
      "affiliations": [
        "Physical Medicine & Rehabilitation, New York University Grossman School of Medicine, New York, New York, USA"
      ],
      "name": "Braden B Weissman"
    },
    {
      "affiliations": [
        "Anesthesiology, Cleveland Clinic, Cleveland, Ohio, USA"
      ],
      "name": "Abraham AlFarra"
    },
    {
      "affiliations": [
        "Pain Medicine, Maywell Health, New York, New York, USA"
      ],
      "name": "Brian G Mayrsohn"
    },
    {
      "affiliations": [
        "Anesthesiology, Pain Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"
      ],
      "name": "Vwaire Orhurhu"
    },
    {
      "affiliations": [
        "Anesthesiology, Pain Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"
      ],
      "name": "Trent Emerick"
    },
    {
      "affiliations": [
        "Division of Pain Medicine, University of California San Diego, San Diego, California, USA"
      ],
      "name": "Timothy Furnish"
    },
    {
      "affiliations": [
        "Division of Pain Medicine, University of California San Diego, San Diego, California, USA"
      ],
      "name": "Joel P Castellanos"
    }
  ],
  "title": "Psilocybin and chronic neuropathic pain: a systematic review",
  "uid": "67a18b57-9a45-5b0b-a4dc-ece6996e37f6"
}