{
  "abstract": "Background and Aims Spinal anesthesia (SA) has become the standard anesthesia technique for cesarean section (CS). Major side effects of SA are hypotension, bradycardia, nausea and shivering. Ondansetron has been studied as a potential preventive drug of SAIH. Despite the promising effects in some studies, much literature recommends further study. The goal of our study was to determine whether the prophylactic administration of ondansetron can attenuate SAIH in patients undergoing CS.Methods A double-blinded randomized clinical trial was conducted on 41 full-term parturients from June to September 2023. Patients were randomly allocated into Group O (n=22), who received ondansetron 4 mg, and Group C (n=19), who received normal saline. All the patients were monitored for blood pressure, heart rate, vasopressor requirement and side effects. The data analysis was carried out with independent samples T-test and Chi-square test.Results Fourteen patients in group C (73,6%) and twelve patients in group O (54,5%) had intraoperative hypotension, but the difference was not statistically significant (P = 0,164). The total phenylephrine requirement in group C was significantly higher than in group O (P = 0,030). Also, the ephedrine dose required in group C was higher than in group O, but the difference was not statistically significant (P = 0,309). There was no statistical difference in mean HR, SBP, DBP and MAP values from minute 0 to minute 40 between the two groups. The incidence of nausea was significantly higher in group C than in group O (P=0,013). Incidence of vomiting was superior in group C, but the difference was not statistically significant (p=0,141). Shivering and pruritus were found in one patient in group C.Conclusions Prophylactic ondansetron was not effective in reducing the incidence of hypotension in parturients undergoing cesarean section, but it did reduce significantly the amount of vasopressor used and the incidence of nausea. Further research is necessary.",
  "authors": [
    {
      "affiliations": [
        "Anaesthesiology, Hospital do Divino Espírito Santo de Ponta Delgada, Ponta Delgada, Portugal"
      ],
      "name": "Sancha Costa Santos"
    },
    {
      "affiliations": [
        "Anaesthesiology, Hospital do Divino Espírito Santo de Ponta Delgada, Ponta Delgada, Portugal"
      ],
      "name": "Helena Silva"
    },
    {
      "affiliations": [
        "Anaesthesiology, Hospital do Divino Espírito Santo de Ponta Delgada, Ponta Delgada, Portugal"
      ],
      "name": "Joaquim Borba"
    },
    {
      "affiliations": [
        "Anaesthesiology, Hospital do Divino Espírito Santo de Ponta Delgada, Ponta Delgada, Portugal"
      ],
      "name": "Rui Freitas da Silva"
    },
    {
      "affiliations": [
        "Serviço Farmacêutico, Hospital do Divino Espírito Santo de Ponta Delgada, Ponta Delgada, Portugal"
      ],
      "name": "Ana Cristina Castanha"
    },
    {
      "affiliations": [
        "Anaesthesiology, Hospital do Divino Espírito Santo de Ponta Delgada, Ponta Delgada, Portugal"
      ],
      "name": "António Paiva"
    }
  ],
  "title": "OP73 Prophylatic ondansetron for prevention of spinal anesthesia induced hypotension in patients undergoing cesarean section: a double blinded randomized clinical trial",
  "uid": "f560c302-911d-5289-ae01-3a36c695aa60"
}