{
  "abstract": "Background and Aims Pethidine is the only member of the opioid family that has clinically important local anaesthetic activity in the dose range normally used for analgesia. This study compares the effects of an intrathecal injection of pethidine combined with bupivacaine versus intrathecal bupivacaine alone in patients undergoing lower extremity re-vasularisation surgeries.Methods In this prospective, randomized, controlled, double-blinded study, 46 participants scheduled for elective lower extremity re-vascularisartion surgeries were randomly allocated into two groups. Group PD (n = 23) received an intrathecal injection of 1 mg/kg preservative-free pethidine combined with 1.5 ml (7.5 mg) of 0.5% hyperbaric bupivacaine, diluted with 0.9% sodium chloride saline to a total volume of 3 mL. Group B (n = 23) received an intrathecal injection of 3 mL (15 mg) of 0.5% hyperbaric bupivacaine alone. The primary outcome measured was the time to the first need for rescue analgesia. Secondary outcomes included spinal anesthesia characteristics, intraoperative hemodynamic stability, and incidence of perioperative adverse events.Results The time to first need for rescue analgesia was significantly longer in Group PD (7.76 ± 0.79 hours) compared to Group B (4.48 ± 0.63 hours). Differences in the onset of sensory and motor blocks between Group PD (6.39 ± 1.12 and 10.09 ± 2.23 minutes, respectively) and Group B (6.43 ± 1.99 and 9.96 ± 2.33 minutes, respectively) were statistically non-significant. Incidence of hypotension and shivering was also less frequent in Group PD than in Group B.Abstract OP45 Figure 1Ethics comittee approvalConclusions Intrathecal administration of 1 mg/kg pethidine plus 7.5 mg bupivacaine 0.5% provided improved spinal anesthesia, with extended postoperative analgesia, minimal intraoperative hemodynamic disturbances, and reduced incidence of shivering compared to bupivacaine alone in patients undergoing lower extremity re-vascularisation surgeries. This approach may be particularly beneficial for surgeries requiring longer time offering a cost-effective alternative to standard local anesthetics.",
  "authors": [
    {
      "affiliations": [
        "Dept of Anaesthesia and Intensive Care, University Hospital Mother Theresa, Tirana, Albania"
      ],
      "name": "Jonela Burimi"
    }
  ],
  "title": "OP45 Effects of intrathecal pethidine in surgical re-vascularisation of lower extremity",
  "uid": "eec7d970-d17d-5ce8-acdb-3537b706275a"
}