{
  "abstract": "Application for ESRA Abstract Prizes:Background and Aims Posterior spinal fusion to correct adolescent idiopathic scoliosis is associated with severe postoperative pain, underscoring the need for effective multimodal analgesia. This study aims to evaluate the analgesic efficacy and safety of intrathecal morphine (ITM) combined with intravenous morphine patient-controlled analgesia (PCA).Methods A retrospective analysis was conducted on a population of 12 adolescents (14–18 years) who underwent posterior spinal fusion between January and May 2025. Patients received general anesthesia and a uniform multimodal analgesic regimen that included weight-based ITM (2–3 µg.kg −1). Post-operatively, intravenous morphine PCA (1 mg bolus, 10-min lockout) ran without basal infusion for 24 h, then continued at 0.3 mL.h−1 until withdrawal on day 2. Pain intensity (NRS 0–10) at rest and on deep breathing or coughing, plus opioid-related adverse events - including pruritus, nausea/vomiting, sedation, respiratory depression, urinary retention and ileus - were assessed for 48 h.Results Amongst 12 patients, median resting NRS was 0.2 ± 0.6 at 6 h, 1.9 ± 1.5 at 24 h and 1.1 ± 1.0 at 48 h and median coughing NRS was 0.8 ± 1.2, 3.4 ± 1.7 and 2.5 ± 1.4, respectively. Additionally, 72% of the population remained NRS ≤ 3 when coughing. Pruritus occurred in 25% and nausea/vomiting in 33% throughout the 48 h; no respiratory depression, urinary retention, ileus or clinically relevant sedation was reported.Conclusions ITM combined with a progressive IV morphine PCA as part of a multimodal analgesic regimen yielded low pain scores and mild side-effects after adolescent scoliosis correction, supporting its routine effective use and contributing evidence for subsequent dose-optimisation investigations.",
  "authors": [
    {
      "affiliations": [
        "Lisbon, Portugal"
      ],
      "name": "Cláudia Vasconcelos"
    },
    {
      "affiliations": [
        "Anestesiologia, ULS São José, Lisboa, Portugal"
      ],
      "name": "Mariana Neves"
    },
    {
      "affiliations": [
        "Anestesiologia, ULS São José, Lisboa, Portugal"
      ],
      "name": "André Parra"
    },
    {
      "affiliations": [
        "Anestesiologia, ULS São José, Lisboa, Portugal"
      ],
      "name": "Susana Cadilha"
    }
  ],
  "title": "P327 Efficacy and safety of weight-based intrathecal morphine for adolescent scoliosis correction: a 12-patient retrospective analysis",
  "uid": "b5db6fd1-ec0a-5fef-82af-b20eef7f3855"
}