{
  "abstract": "Please confirm that an ethics committee approval has been applied for or granted: Yes: I’m uploading the Ethics Committee Approval as a PDF file with this abstract submission Application for ESRA Abstract Prizes: I apply as an Anesthesiologist (Aged 35 years old or less)Background and Aims Background: Percutaneous nephrolithotomy and placement of nephrostomy tube is performed for renal stones > 2 cm in diameter. Attempts have been made to infiltrate local anaesthetics with or without adjuvants into the surgical site to reduce pain. We hypothesized that there would be a significant prolongation of the analgesic effect of local anaesthetic instillation along nephrostomy tube due to the adjuvant dexamethasone. Aims/Objectives: We compared the duration of analgesia in terms of the maximum numeric rating scale at 2,4,6,12,24, 48 and 60 hours postoperatively between Ropivacaine (R) and Ropivacaine-dexamethasone (R+D) groups. The total cumulative dose of Ropivacaine and Dexamethasone and the rescue analgesic fentanyl along with ESR and CRP were also determined.Methods After ethical approval and CTRI registration (CTRI/2020/03/024332), 64 ASA I&II adult patients were enrolled in this randomized double blinded prospective study divided into Group R – received 20 ml 0.2% Ropivacaine and Group R+D – received 20 ml 0.2% Ropivacaine with dexamethasone 8 mg, injected through a multi-lumen wound infiltration catheter.Results The demographic profile of patients was similar in both the groups. The mean duration of analgesia was longer in Group R+D (21.3 +/- 2.1 hrs) vs Group R (10+/-1.9 hrs, p = 0.001). The mean NRS scores of Group R+D were significantly lower at all time intervals (p = 0.001). Also, the cumulative dose of ropivacaine and the total use of fentanyl postoperatively in group R was much higher (70+/-10.4 vs 56+/- 8.9 mcg, p = 0.02). The CRP levels were significantly lower in Group R+D (13.8 +/- 1.5 vs 23.1 +/- 1.2 mg/L, p=0.001 and 16.5 +/- 1.3 vs 28.5 +/- 1.7 mg/L, p=0.001, at 24 and 48 hours respectively).Conclusions We conclude that dexamethasone can be used as a suitable adjuvant to intermittent local anaesthetic infiltration after PCNL with nephrostomy tube for the prolongation of analgesia.",
  "authors": [
    {
      "affiliations": [
        "Dept of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research Chandigarh India, Chandigarh, India"
      ],
      "name": "Shyam Charan Meena"
    },
    {
      "affiliations": [
        "Dept of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research Chandigarh India, Chandigarh, India"
      ],
      "name": "Ankur Luthra"
    },
    {
      "affiliations": [
        "Dept of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research Chandigarh India, Chandigarh, India"
      ],
      "name": "Rajeev Chauhan"
    },
    {
      "affiliations": [
        "Dept of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research Chandigarh India, Chandigarh, India"
      ],
      "name": "Vernika Ahuja"
    }
  ],
  "title": "P231 Effect of dexamethasone addition to ropivacaine on post-operative analgesia after percutaneous nephrolithotomy: a prospective randomized controlled trial",
  "uid": "9a4c792f-cb9a-5e09-a14d-8a71437165ab"
}