{
  "abstract": "Please confirm that an ethics committee approval has been applied for or granted: Yes: I’m uploading the Ethics Committee Approval as a PDF file with this abstract submissionApplication for ESRA Abstract PrizesBackground and Aims Spinal anesthesia is the most widely used and effective anesthesia technique for total hip arthroplasty (THA). Local anesthetic agents can be combined with adjuvants to improve analgesic quality and duration. We hypothesized that intrathecal nalbuphine, added to levobupivacaine, would enhance intraoperative and postoperative analgesia.Methods After informed consent, 60 patients, aged 18–80 years, scheduled for THA, were randomized into two groups. Group N (n=30) received 3,2 mL of 0.5% levobupivacaine with 0.4 mg nalbuphine intrathecally, while Group L (n=30) received plain 3.2 mL levobupivacaine 0.5%. Exclusion criteria included ASA score > III, BMI > 40, severe psychiatric or cognitive disorders, and allergies to study drugs. The anesthesia team was the same throughout the study, and both patients and evaluators were blinded to group allocation. All patients received 1 g paracetamol intraoperatively, continued every 6 hours postoperatively, and a pericapsular nerve group (PENG) block. The primary outcome was acute postoperative pain, assessed by total morphine use within the first 24 hours. Morphine was administered using the MicrelRythmicEvolution PCA pump, and MicrelCare software.Results Morphine consumption at 6, 12 and 24 hours was significantly higher in group L (p<0.001). At all time points, the NRS score at rest and at motion was significantly greater in group L (p<0.001). The duration of sensory and motor blockade were significantly higher in the group N (p<0.001). The incidence of hypotension was lower in group N.Abstract P263 Table 1Morphine administration, by groupAbstract P263 Table 2NRS scores, by groupConclusions Nalbuphine as an adjuvant in spinal anesthesia seems to be safe and effective, reducing postoperative pain and opioid consumption in patients undergoing THA.",
  "authors": [
    {
      "affiliations": [
        "Department of Anesthesiology, Asklepieio Voulas General Hospital, Athens, Greece"
      ],
      "name": "Anastasios Bontozis"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Asklepieio Voulas General Hospital, Athens, Greece"
      ],
      "name": "Ioanna Pikasi"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Asklepieio Voulas General Hospital, Athens, Greece"
      ],
      "name": "Magdalini Papageorgiou"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Asklepieio Voulas General Hospital, Athens, Greece"
      ],
      "name": "Maria Tileli"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Asklepieio Voulas General Hospital, Athens, Greece"
      ],
      "name": "Michail Tsagkaris"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Asklepieio Voulas General Hospital, Athens, Greece"
      ],
      "name": "Alexandros Makris"
    }
  ],
  "title": "P263 The effect of nalbuphine as an adjuvant to levobupivacaine in subarachnoid anesthesia in total hip arthroplasty. A double-blind, randomized, controlled study",
  "uid": "81db852d-1659-5040-ac30-a329daf311e0"
}