{
  "abstract": "Background and Aims Cannabidiol (CBD) is a non-intoxicating phytocannabinoid with limited clinical evidence of its pain relieving and opioid sparing properties. In the US, an oral cannabidiol solution, Epidiolex®, is approved by the FDA for the treatment of intractable seizures. We conducted an off-label pilot study of Epidiolex® in patients undergoing bilateral total knee arthroplasty (BTKA) to assess effects on opioid requirements, pain, inflammation, tolerability, sleep, mood, and pharmacokinetics.Methods After IRB-approval and trial registration ( NCT04749628), 36 patients undergoing BTKA were randomized to receive four perioperative doses of placebo (Ora-Sweet SF) (n=12), 400 mg (n=12) or 800 mg (n=12) CBD oral solution (Epidiolex®) (figure 1) with standardized anesthesia and analgesia regimen including regional techniques. Descriptive statistics were used to summarize patient and case characteristics and outcomes; pairwise t-tests were used to compare cumulative first 72-hour opioid consumption (primary outcome) between the three groups.Results Patient and case characteristics are summarized in table 1. Compared to placebo, patients who received 400 mg CBD had 30% lower cumulative 72-hour opioid requirements (mean: 209 MMEs versus 144 MMEs; p=0.04), with no difference between placebo and 800 mg CBD (p=0.9) or between 400 mg and 800 mg CBD (p=0.09). Patients randomized to the 400 mg CBD also had lower pain scores, while patients in the 800 mg CBD had more side-effects compared to placebo and 400 mg CBD. Additional outcomes are summarized in table 2.Abstract OP60 Figure 1CONSORT flow diagramAbstract OP60 Table 1Demographics and case characteristicsAbstract OP60 Table 2Analgesic use, IL-6 levels, pain scores, sleep efficiency and side-effectsConclusions Our pilot findings suggest promising efficacy for pain relief and opioid reduction with 400 mg CBD. Adequately powered randomized controlled trials are needed and will help elucidate potential biphasic effects.",
  "authors": [
    {
      "affiliations": [
        "Pain Prevention Research Center (PPRC), Department of Anesthesiology, Critical Care and Pain Management, Hospital for Special Surgery, New York, USA"
      ],
      "name": "William Chan"
    },
    {
      "affiliations": [
        "Pain Prevention Research Center (PPRC), Department of Anesthesiology, Critical Care and Pain Management, Hospital for Special Surgery, New York, USA",
        "Department of Anesthesiology, Weill Cornell Medicine, New York, USA"
      ],
      "name": "Jiabin Liu"
    },
    {
      "affiliations": [
        "Pain Prevention Research Center (PPRC), Department of Anesthesiology, Critical Care and Pain Management, Hospital for Special Surgery, New York, USA",
        "Department of Anesthesiology, Weill Cornell Medicine, New York, USA"
      ],
      "name": "Lila Baaklini"
    },
    {
      "affiliations": [
        "Pain Prevention Research Center (PPRC), Department of Anesthesiology, Critical Care and Pain Management, Hospital for Special Surgery, New York, USA",
        "Department of Anesthesiology, Weill Cornell Medicine, New York, USA"
      ],
      "name": "Meghan Kirksey"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Critical Care and Pain Management, Hospital for Special Surgery, New York, USA"
      ],
      "name": "Alex Illescas"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Weill Cornell Medicine, New York, USA",
        "Department of Anesthesiology, Critical Care and Pain Management, Hospital for Special Surgery, New York, USA"
      ],
      "name": "Seth Waldman"
    },
    {
      "affiliations": [
        "Department of Anesthesiology, Weill Cornell Medicine, New York, USA",
        "Department of Anesthesiology, Critical Care and Pain Management, Hospital for Special Surgery, New York, USA"
      ],
      "name": "Kethy Jules-Elysee"
    },
    {
      "affiliations": [
        "Pain Prevention Research Center (PPRC), Department of Anesthesiology, Critical Care and Pain Management, Hospital for Special Surgery, New York, USA",
        "Department of Anesthesiology, Weill Cornell Medicine, New York, USA"
      ],
      "name": "Alexandra Sideris"
    }
  ],
  "title": "OP60 Effects of cannabidiol (CBD) oral solution in patients undergoing bilateral total knee arthroplasty: a randomized, controlled, parallel, triple blind, pilot study",
  "uid": "7dfb4785-fb0b-57ff-962e-db41f356efb3"
}