{
  "abstract": "Background and Aims Caesarean delivery rates are rising globally, from 7% in 1990 to 21% in 2018, with projections of 29% by 2030 as per World Health Organisation. 1 While neuraxial anaesthesia (NA) has been the gold standard for caesarean sections, general anaesthesia (GA) may be warranted in certain conditions. Studies have linked exposure to GA at birth with poorer neonatal outcomes, though these findings are based on retrospective data and neonatal outcomes was determined using Apgar scores and umbilical artery pH. Stress disrupts homeostasis and triggers hormonal responses, with anaesthesia itself acting as a significant stressor that may influence fetal development altering the hypothalamic-pituitary-adrenal (HPA) axis.2 The study aims to compare the stress response in newborn during caesarean section between general and neuraxial anaesthesia.Methods This is a prospective observational single centric study. The first group comprised of newborns delivered under general anaesthesia (GA group) and second group are delivered under neuraxial anaesthesia (NA group). Institutional Ethics Committee approval obtained. The decision for neuraxial or general anaesthesia was at the discretion of the anaesthesiologist and obstetrician managing the case. All women received standard anaesthetic care as per Institutional protocol. Umbilical cord blood samples were collected in serum vial following placental delivery from the umbilical cord vein. The ELISA method was utilized for assessing interleukin-6 (IL-6) and cortisol levels in the blood samples of both groups.Results Data of n=24 participants were analysed in this interim analysis. Cortisol levels was significantly higher in neonates delivered under GA group as compared to NA group (p < 0.001). The mean IL-6 concentration in GA group was significantly higher (p < 0.001) in comparison to NA group.Conclusions This study showed that the stress response biomarkers in newborn were higher under general anaesthesia than neuraxial anaesthesia administered to women undergoing caesarean section in our study.",
  "authors": [
    {
      "affiliations": [
        "Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences New Delhi, Delhi, India"
      ],
      "name": "Choro Athiphro Kayina"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences New Delhi, Delhi, India"
      ],
      "name": "K Aparna Sharma"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences New Delhi, Delhi, India"
      ],
      "name": "Neena Malhotra"
    },
    {
      "affiliations": [
        "Department of Pediatrics, All India Institute of Medical Sciences New Delhi, Delhi, India"
      ],
      "name": "Lata Singh"
    },
    {
      "affiliations": [
        "Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences New Delhi, Delhi, India"
      ],
      "name": "Puneet Khanna"
    }
  ],
  "title": "EP191 Comparison of stress response in newborn delivered via caesarean section under general anaesthesia versus neuraxial anaesthesia: a prospective observational study",
  "uid": "3868bab4-37cc-55b3-8eb2-ff59ea54cfe7"
}