{
  "abstract": "The interplay between skin and neurological disorders is well recognised, given the shared embryological origin of both skin and nervous system cells from the ectoderm. Certain cutaneous manifestations may guide the neurological workup and contribute to a more accurate diagnosis. We report a 20-year-old man with drug-resistant epilepsy and developmental regression since childhood, who had characteristic skin findings compatible with ichthyosis. Despite the broad differential diagnosis for these neurological manifestations, recognising the skin involvement was important in guiding the genetic investigation, ultimately narrowing the diagnosis to the group of neuro-ichthyotic syndromes.",
  "authors": [
    {
      "affiliations": [
        "Division of General Neurology, Ataxia and Neurorheumatology Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil"
      ],
      "name": "Julia de Oliveira Xavier Ramos"
    },
    {
      "affiliations": [
        "Division of General Neurology, Ataxia and Neurorheumatology Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil"
      ],
      "name": "Pedro Fraiman"
    },
    {
      "affiliations": [
        "Division of General Neurology, Ataxia and Neurorheumatology Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil"
      ],
      "name": "Thiago Yoshinaga Tonholo Silva"
    },
    {
      "affiliations": [
        "Division of General Neurology, Ataxia and Neurorheumatology Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil"
      ],
      "name": "Rubens Paulo Araújo Salomão"
    },
    {
      "affiliations": [
        "Division of General Neurology, Ataxia and Neurorheumatology Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil"
      ],
      "name": "José Luiz Pedroso"
    },
    {
      "affiliations": [
        "Division of General Neurology, Ataxia and Neurorheumatology Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil"
      ],
      "name": "Orlando G P Barsottini"
    }
  ],
  "title": "Neuroichthyosis: the interplay between brain and skin",
  "uid": "66a6eb7d-e2e9-522d-a91a-9c80af4aa612"
}