{
  "abstract": "A 22-year-old man developed acute fever and malaise. On the third day of fever, he had a dull-aching bilateral headache and orbital pain, predominantly right-sided, and photophobia. He had been previously healthy and lived in Bangkok, Thailand. Neurological examination was normal, without meningeal irritation, cortical lobe signs or interhemispheric disconnection syndrome. MR scan of brain using diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) sequences showed a non-enhancing focal restricted diffusion lesion in the splenium part of the corpus callosum, representing a ‘dot sign’ ( figure 1 , Panels A-B). MR imaging using T2-weighted fluid attenuation inversion recovery (T2/FLAIR) sequences showed a mildly hyperintense lesion in the splenium (figure 1 , Panel C). Serum dengue NS1 antigen was positive, but dengue virus-specific IgM and IgG antibodies were negative. Serum multiplex PCR confirmed dengue virus infection. With supportive treatment, he recovered with no residual neurological deficits. Follow-up MR imaging showed complete resolution of the corpus callosal lesion (image not shown).",
  "authors": [
    {
      "affiliations": [
        "Neurological Institute, University Hospitals, Cleveland Medical Center, Case Western Reserve University Hospital, Cleveland, Ohio, USA",
        "Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"
      ],
      "name": "Thanapoom Taweephol"
    },
    {
      "affiliations": [
        "Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"
      ],
      "name": "Kanisa Jitpanya"
    },
    {
      "affiliations": [
        "Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand",
        "Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA"
      ],
      "name": "Varote Shotelersuk"
    },
    {
      "affiliations": [
        "Department of Medicine, Chaophraya Abhaibhubejhr Hospital, Prachinburi, Thailand"
      ],
      "name": "Juthamas Rianaree"
    },
    {
      "affiliations": [
        "Department of Medicine, King Mongkut’s Institute of Technology Ladkrabang, Bangkok, Thailand",
        "Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"
      ],
      "name": "Chayoot Marukatat"
    },
    {
      "affiliations": [
        "Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand",
        "Thai Red Cross Emerging Infectious Diseases and Health Science Centre, King Chulalongkorn Memorial Hospital, Bangkok, Thailand"
      ],
      "name": "Pasin Hemachudha"
    },
    {
      "affiliations": [
        "Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand",
        "Comprehensive Headache and Orofacial Pain (CHOP) Service and Research Group, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"
      ],
      "name": "Prakit Anukoolwittaya"
    },
    {
      "affiliations": [
        "Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand",
        "Chulalongkorn Centre of Excellence for Parkinson’s Disease & Related Disorders, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand"
      ],
      "name": "Warongporn Phuenpathom"
    },
    {
      "affiliations": [
        "Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand",
        "Healthcare-Associated Infection Research Group STAR, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"
      ],
      "name": "Voraphoj Nilaratanakul"
    },
    {
      "affiliations": [
        "Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand",
        "Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand",
        "Comprehensive Headache and Orofacial Pain (CHOP) Service and Research Group, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand",
        "Chula Neuroscience Center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand"
      ],
      "name": "Thanakit Pongpitakmetha"
    }
  ],
  "title": "Dot sign at the splenium of corpus callosum in dengue virus infection",
  "uid": "52ba4605-f244-5bd1-a12c-172754ce0a7a"
}