{
  "abstract": "Chimeric antigen receptor T cells (CAR-T cells) have revolutionised cancer treatment by offering personalised therapy of unprecedented efficacy to patients with relapsed B-cell malignancies and myeloma. CAR-T cells are designed selectively to target CD19 or other B-cell antigens with high affinity, leading to a potent immune response and effective killing of malignant B cells. More recently, CAR-T treatment has been shown to be safe and effective in a very limited number of patients with severe, refractory autoimmune conditions such as systemic lupus erythematosus, systemic sclerosis and myositis. This paper describes the early use and feasibility of CAR-T therapies in the treatment of refractory autoimmune neurological diseases.",
  "authors": [
    {
      "affiliations": [
        "Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, England, UK",
        "Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, England, UK"
      ],
      "name": "Frederick W Vonberg"
    },
    {
      "affiliations": [
        "Department of Neurology, University Hospital of Wales, Cardiff, Wales, UK",
        "Department of Psychological Medicine and Clinical Neuroscience, Cardiff University, Cardiff, Wales, UK"
      ],
      "name": "Benjamin E Schroeder"
    },
    {
      "affiliations": [
        "Department of Neurology, The Royal London Hospital, London, England, UK"
      ],
      "name": "Amy Edwards"
    },
    {
      "affiliations": [
        "Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England, UK",
        "Department of Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, England, UK"
      ],
      "name": "Bo Sun"
    },
    {
      "affiliations": [
        "Manchester Centre for Clinical Neurosciences, Salford Royal Hospital, Salford, England, UK"
      ],
      "name": "Ryan Y Keh"
    },
    {
      "affiliations": [
        "Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England, UK",
        "Department of Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, England, UK"
      ],
      "name": "Mohammad Reza Ashraghi"
    },
    {
      "affiliations": [
        "Department of Neurology, King’s College Hospital NHS Foundation Trust, London, England, UK"
      ],
      "name": "Dorothy Joe"
    },
    {
      "affiliations": [
        "Department of Neurology, The Royal London Hospital, London, England, UK"
      ],
      "name": "Nikos Gorgoraptis"
    },
    {
      "affiliations": [
        "Department of Neuro-oncology, National Hospital for Neurology and Neurosurgery, London, England, UK"
      ],
      "name": "Jeremy Rees"
    },
    {
      "affiliations": [
        "Department of Neurology, Chelsea and Westminster Hospital, London, England, UK"
      ],
      "name": "Nicholas W S Davies"
    },
    {
      "affiliations": [
        "Department of Neurology, King’s College Hospital NHS Foundation Trust, London, England, UK"
      ],
      "name": "Gerald Finnerty"
    },
    {
      "affiliations": [
        "Department of Neurology, University Hospital of Wales, Cardiff, Wales, UK",
        "Department of Psychological Medicine and Clinical Neuroscience, Cardiff University, Cardiff, Wales, UK"
      ],
      "name": "Mark Willis"
    },
    {
      "affiliations": [
        "Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England, UK",
        "Department of Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, England, UK"
      ],
      "name": "Maria Isabel Leite"
    },
    {
      "affiliations": [
        "Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany"
      ],
      "name": "Ralf Gold"
    },
    {
      "affiliations": [
        "Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany"
      ],
      "name": "Jeremias Motte"
    },
    {
      "affiliations": [
        "Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, England, UK",
        "Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, England, UK"
      ],
      "name": "Aisling S Carr"
    },
    {
      "affiliations": [
        "Department of Neurology, The Royal London Hospital, London, England, UK"
      ],
      "name": "Stephen Keddie"
    },
    {
      "affiliations": [],
      "name": "On behalf of the New and Emerging Oncotherapeutic Neurotoxicity (NEON) Network"
    }
  ],
  "title": "CAR-T cells in the treatment of neurological autoimmune diseases",
  "uid": "15a88626-4316-51e7-b245-c69018807757"
}